ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer

Li Fang Lin, Chih Hung Chuang, Chien Feng Li, Ching Chun Liao, Chun Pei Cheng, Tian Lu Cheng, Meng Ru Shen, Joseph T. Tseng, Wen Chang, Wen Hwa Lee, Ju Ming Wang

研究成果: 雜誌貢獻文章

44 引文 斯高帕斯(Scopus)

摘要

The BRCA1-interacted transcriptional repressor ZBRK1 has been associated with antiangiogenesis, but direct evidence of a tumor suppressor role has been lacking. In this study, we provide evidence of such a role in cervical carcinoma. ZBRK1 levels in cervical tumor cells were significantly lower than in normal cervical epithelial cells. In HeLa cervical cancer cells, enforced expression inhibited malignant growth, invasion, and metastasis in a variety of in vitro and in vivo assays. Expression of the metalloproteinase MMP9, which is known to be an important driver of invasion and metastasis, was found to be inversely correlated with ZBRK1 in tumor tissues and a target for repression in tumor cells. Our findings suggest that ZBRK1 acts to inhibit metastasis of cervical carcinoma, perhaps by modulating MMP9 expression.

原文英語
頁(從 - 到)192-201
頁數10
期刊Cancer Research
70
發行號1
DOIs
出版狀態已發佈 - 一月 1 2010
對外發佈Yes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Lin, L. F., Chuang, C. H., Li, C. F., Liao, C. C., Cheng, C. P., Cheng, T. L., Shen, M. R., Tseng, J. T., Chang, W., Lee, W. H., & Wang, J. M. (2010). ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer. Cancer Research, 70(1), 192-201. https://doi.org/10.1158/0008-5472.CAN-09-2641