Z-DNA forms without an alternating purine-pyrimidine sequence in solution

Juli Feigon, Andrew H.J. Wang, Gijs A. Van Der Marel, Jacques H. Van Boom, Alexander Rich

研究成果: 雜誌貢獻文章同行評審

52 引文 斯高帕斯(Scopus)

摘要

Nuclear magnetic resonance spectra (proton and phosphorus-31) and ultraviolet absorption spectra of the DNA decamer d(br5CGbr 5CGATbr5CGbr5CG), in which the central two adenine-thymine base pairs are out of order with the rest of the purine-pyrimidine alternation sequence, indicate that under appropriate solvent conditions (high salt and methanol) the molecule undergoes a structural transition from a right-handed B-DNA conformation to a left-handed Z-DNA conformation. Measurements of the two-dimensional nuclear Overhauser effect on the decamer indicate that all of the guanines as well as the two equivalent thymines adopt the syn conformation.

原文英語
頁(從 - 到)82-84
頁數3
期刊Science
230
發行號4721
DOIs
出版狀態已發佈 - 1985
對外發佈

ASJC Scopus subject areas

  • 多學科

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