Yes-associated protein is not an independent prognostic marker in breast cancer

Shyr Ming Sheen-Chen, Chun Ying Huang, Ching Hua Tsai, Yueh Wei Liu, Shih Chung Wu, Chao Cheng Huang, Hock Liew Eng, Yi Chia Chan, Sheung Fat Ko, Rei Ping Tang

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

Background: The development of tissue microarray (TMA) technology has provided the opportunity to perform analyses of tissue samples on a large scale in an uniform fashion. This study was designed with the use of TMA to explore the Yes-associated protein (YAP) status in breast cancer. Patients and Methods: YAP expression in tumor and tumor-free samples from 94 patients with primary breast cancer was analyzed by TMA. The clinicopathological data for age, estrogen receptor status, histological grading and TNM staging were also collected. Results: There were 29 patients (30.8%) with 1+ expression, in YAP, 59 patients (62.8%) with 2+ expression and 6 (6.4%) with 3+ expression. There was no significant relationship between YAP expression and the other clinicopathological variables. By multivariate analysis, YAP expression failed to produce any significant relationship with the overall survival rate. Conclusion: YAP expression is not an independent prognostic factor in patients with breast cancer.

原文英語
頁(從 - 到)3321-3326
頁數6
期刊Anticancer Research
32
發行號8
出版狀態已發佈 - 八月 1 2012

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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