Why context matters? Divisive normalization and canonical microcircuits in psychiatric disorders

Georg Northoff, Hajime Mushiake

研究成果: 雜誌貢獻回顧型文獻同行評審

5 引文 斯高帕斯(Scopus)

摘要

Neural activity on cellular, regional, and behavioral levels shows context-dependence. Here we suggest the processing of input-output relationships in terms divisive normalization (DN), including (i) summing/averaging inputs and (ii) normalizing output against input stages, as a computational mechanism to underlie context-dependence. Input summation and output normalization are mediated by input-output relationships in canonical microcircuits (CM). DN/CM are altered in psychiatric disorders like schizophrenia or depression whose various symptoms can be characterized by abnormal context-dependence.

原文英語
頁(從 - 到)130-140
頁數11
期刊Neuroscience Research
156
DOIs
出版狀態已發佈 - 七月 2020

ASJC Scopus subject areas

  • 神經科學 (全部)

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