Well-defined mesoporous nanostructure modulates three-dimensional interface energy transfer for two-photon activated photodynamic therapy

Shih Hsun Cheng, Cheng Chih Hsieh, Nai Tzu Chen, Chia Hui Chu, Ching Mao Huang, Pi Tai Chou, Fan Gang Tseng, Chung Shi Yang, Chung Yuan Mou, Leu Wei Lo

研究成果: 雜誌貢獻文章同行評審

53 引文 斯高帕斯(Scopus)

摘要

Two-photon activated-photodynamic therapy (TPA-PDT) allows for spatially selective treatment of cancers, and enhances the tissue penetration depth of incident light. The three dimensional (3D) interface energy transfers in hexagonal mesoporous silica nanoparticles (MSNs) can significantly enhance the photodynamic effect. By providing a well-defined mesoporous nanostructure, we established an efficient and controllable energy transfer mechanism via the facile modification of a two-photon antenna molecule and photosensitizer on different topological domains in the MSN. The cytotoxicity induced by the singlet oxygen, generated following relay of energy transfer, was demonstrated in both in vitro and in vivo breast cancer models. Therefore, our results contribute new insight to the highly efficient energy transfer within a single nanoparticle for two-photon activated PDT, worthwhile for studying its potential for development in clinical translation.

原文英語
頁(從 - 到)552-563
頁數12
期刊Nano Today
6
發行號6
DOIs
出版狀態已發佈 - 12月 2011
對外發佈

ASJC Scopus subject areas

  • 生物技術
  • 生物工程
  • 生物醫學工程
  • 材料科學(全部)
  • 藥學科學

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