Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

Dun Jen Hsiao, Lawrence Shih Hsin Wu, Shih Yi Huang, Eugene Lin

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34 引文 斯高帕斯(Scopus)

摘要

The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P

原文英語
頁(從 - 到)730-733
頁數4
期刊Pharmacogenetics and Genomics
19
發行號9
DOIs
出版狀態已發佈 - 9月 2009

ASJC Scopus subject areas

  • 遺傳學
  • 分子生物學
  • 分子醫學
  • 遺傳學(臨床)

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