Weekly CAF chemotherapy for advanced breast cancer patients

Wei Shou Hwang; Chao A. Hsiung; Wann Sheng Ko; Chang Chung Wang; Jang Yang Chang; Gi Ming Lai; Ruey Kuen Hsieh; Chao Jung Tsao; Li Tzong Chen; Chi Kong Law; Ann Lii Cheng; Sheng F. Fan; Cheng Hwai Tzeng; Tzeon Jye Chiou; Jacqueline Whang-Peng

Weekly CAF chemotherapy for advanced breast cancer patients

Wei Shou Hwang, Chao A. Hsiung, Wann Sheng Ko, Chang Chung Wang, Jang Yang Chang, Gi Ming Lai, Ruey Kuen Hsieh, Chao Jung Tsao, Li Tzong Chen, Chi Kong Law, Ann Lii Cheng, Sheng F. Fan, Cheng Hwai Tzeng, Tzeon Jye Chiou, Jacqueline Whang-Peng

研究成果: 雜誌貢獻 › 文章 › 同行評審

1 引文斯高帕斯（Scopus）

摘要

In a prospective phase II study, 102 women with advanced breast cancer were treated with low doses of cyclophosphamide, Adriamycin and 5-fluorouracil (CAF) at weekly intervals by intravenous injection. Seventy-five patients were evaluable for treatment response and the overall response rate was 52% (95% confidence interval, 41-63%). Of the evaluable patients, 15% had complete response and 37% had partial response. The median survival after therapy was 15.6 months, the median time to progression was 6.8 months and the median duration of response was 9.1 months. The main toxicities were mild vomiting and moderate myelosuppression. There was only 1 patient who experienced heart failure. Weekly CAF appears to have an efficacy with tolerable side effects comparable to standard CAF with an every-3-week schedule.

原文	英語
頁（從 - 到）	293-297
頁數	5
期刊	Oncology
卷	54
發行號	4
出版狀態	已發佈 - 7月 1997
對外發佈	是

ASJC Scopus subject areas

癌症研究
腫瘤科

UN SDG

此研究成果有助於以下永續發展目標

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title = "Weekly CAF chemotherapy for advanced breast cancer patients",

abstract = "In a prospective phase II study, 102 women with advanced breast cancer were treated with low doses of cyclophosphamide, Adriamycin and 5-fluorouracil (CAF) at weekly intervals by intravenous injection. Seventy-five patients were evaluable for treatment response and the overall response rate was 52% (95% confidence interval, 41-63%). Of the evaluable patients, 15% had complete response and 37% had partial response. The median survival after therapy was 15.6 months, the median time to progression was 6.8 months and the median duration of response was 9.1 months. The main toxicities were mild vomiting and moderate myelosuppression. There was only 1 patient who experienced heart failure. Weekly CAF appears to have an efficacy with tolerable side effects comparable to standard CAF with an every-3-week schedule.",

keywords = "Breast cancer, advanced, CAF, weekly, Phase II trial",

author = "Hwang, {Wei Shou} and Hsiung, {Chao A.} and Ko, {Wann Sheng} and Wang, {Chang Chung} and Chang, {Jang Yang} and Lai, {Gi Ming} and Hsieh, {Ruey Kuen} and Tsao, {Chao Jung} and Chen, {Li Tzong} and Law, {Chi Kong} and Cheng, {Ann Lii} and Fan, {Sheng F.} and Tzeng, {Cheng Hwai} and Chiou, {Tzeon Jye} and Jacqueline Whang-Peng",

year = "1997",

month = jul,

language = "English",

volume = "54",

pages = "293--297",

journal = "Oncology",

issn = "0030-2414",

publisher = "UBM Medica Healthcare Publications",

number = "4",

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T1 - Weekly CAF chemotherapy for advanced breast cancer patients

AU - Hwang, Wei Shou

AU - Hsiung, Chao A.

AU - Ko, Wann Sheng

AU - Wang, Chang Chung

AU - Chang, Jang Yang

AU - Lai, Gi Ming

AU - Hsieh, Ruey Kuen

AU - Tsao, Chao Jung

AU - Chen, Li Tzong

AU - Law, Chi Kong

AU - Cheng, Ann Lii

AU - Fan, Sheng F.

AU - Tzeng, Cheng Hwai

AU - Chiou, Tzeon Jye

AU - Whang-Peng, Jacqueline

PY - 1997/7

Y1 - 1997/7

N2 - In a prospective phase II study, 102 women with advanced breast cancer were treated with low doses of cyclophosphamide, Adriamycin and 5-fluorouracil (CAF) at weekly intervals by intravenous injection. Seventy-five patients were evaluable for treatment response and the overall response rate was 52% (95% confidence interval, 41-63%). Of the evaluable patients, 15% had complete response and 37% had partial response. The median survival after therapy was 15.6 months, the median time to progression was 6.8 months and the median duration of response was 9.1 months. The main toxicities were mild vomiting and moderate myelosuppression. There was only 1 patient who experienced heart failure. Weekly CAF appears to have an efficacy with tolerable side effects comparable to standard CAF with an every-3-week schedule.

AB - In a prospective phase II study, 102 women with advanced breast cancer were treated with low doses of cyclophosphamide, Adriamycin and 5-fluorouracil (CAF) at weekly intervals by intravenous injection. Seventy-five patients were evaluable for treatment response and the overall response rate was 52% (95% confidence interval, 41-63%). Of the evaluable patients, 15% had complete response and 37% had partial response. The median survival after therapy was 15.6 months, the median time to progression was 6.8 months and the median duration of response was 9.1 months. The main toxicities were mild vomiting and moderate myelosuppression. There was only 1 patient who experienced heart failure. Weekly CAF appears to have an efficacy with tolerable side effects comparable to standard CAF with an every-3-week schedule.

KW - Breast cancer, advanced

KW - CAF, weekly

KW - Phase II trial

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M3 - Article

C2 - 9216853

AN - SCOPUS:0030904233

SN - 0030-2414

VL - 54

SP - 293

EP - 297

JO - Oncology

JF - Oncology

IS - 4

ER -

Weekly CAF chemotherapy for advanced breast cancer patients

摘要

ASJC Scopus subject areas

UN SDG

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指紋

引用此