Weak coupling between intracellular feedback loops explains dissociation of clock gene dynamics

Christoph Schmal, Daisuke Ono, Jihwan Myung, J. Patrick Pett, Sato Honma, Ken Ichi Honma, Hanspeter Herzel, Isao T. Tokuda

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Circadian rhythms are generated by interlocked transcriptional-translational negative feedback loops (TTFLs), the molecular process implemented within a cell. The contributions, weighting and balancing between the multiple feedback loops remain debated. Dissociated, free-running dynamics in the expression of distinct clock genes has been described in recent experimental studies that applied various perturbations such as slice preparations, light pulses, jet-lag, and culture medium exchange. In this paper, we provide evidence that this "presumably transient" dissociation of circadian gene expression oscillations may occur at the single-cell level. Conceptual and detailed mechanistic mathematical modeling suggests that such dissociation is due to a weak interaction between multiple feedback loops present within a single cell. The dissociable loops provide insights into underlying mechanisms and general design principles of the molecular circadian clock.

原文英語
文章編號e1007330
頁(從 - 到)e1007330
期刊PLoS Computational Biology
15
發行號9
DOIs
出版狀態已發佈 - 九月 12 2019

ASJC Scopus subject areas

  • 生態學、進化論、行為學與系統學
  • 建模與模擬
  • 生態學
  • 分子生物學
  • 遺傳學
  • 細胞與分子神經科學
  • 計算機理論與數學

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