Volume and neuron number of the mediodorsal thalamic nucleus in schizophrenia: A replication study

Peter Danos, Andrea Schmidt, Bruno Baumann, Hans Gert Bernstein, Georg Northoff, Renate Stauch, Dieter Krell, Bernhard Bogerts

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48 引文 斯高帕斯(Scopus)


Previous neuropathological studies on the mediodorsal thalamic nucleus (MD) in schizophrenia have yielded conflicting results. While some studies suggested that patients with schizophrenia have a pronounced reduction of the volume and neuron number in the MD, more recent data have not found anatomical alterations in this thalamic nucleus. However, most studies have considerable methodological shortcomings. In the present study, we investigated the volume, neuron density and neuron number in the left and right MD in patients with schizophrenia (n = 20) and normal control subjects without neuropsychiatric disorders (n = 18). Patients with schizophrenia showed no significant difference in neuron density and total neuron number in the MD. Compared with the control group, patients with schizophrenia had a smaller MD volume in both hemispheres, a difference that approached significance in the left MD (- 7.3%) when the whole brain volume was included as a covariate. No significant main group effect of diagnosis was found for the right MD volume. There were no significant correlations between MD volume, neuron density, total neuron number and the duration of illness or the age of the patients. Taken together, the present results suggest that schizophrenia is associated with a moderate volume reduction in the left mediodorsal thalamic nucleus, while the neuron density and the total neuron number are unchanged.
頁(從 - 到)281-289
期刊Psychiatry Research - Neuroimaging
出版狀態已發佈 - 12月 30 2005

ASJC Scopus subject areas

  • 精神病學和心理健康
  • 放射學、核子醫學和影像學
  • 生物精神病學
  • 心理學(全部)


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