Vitamin D receptor gene polymorphisms and distinct clinical phenotypes of hepatitis B carriers in Taiwan

Y. W. Huang, Y. T. Liao, W. Chen, C. L. Chen, J. T. Hu, C. J. Liu, M. Y. Lai, P. J. Chen, D. S. Chen, S. S. Yang, J. H. Kao

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35 引文 斯高帕斯(Scopus)

摘要

Vitamin D exhibits immunomodulatory and antiproliferative effects through vitamin D receptor (VDR) in chronic infections and cancers. We genotyped the BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) polymorphisms of VDR gene in 250 Taiwanese chronic hepatitis B virus (HBV) carriers who were categorized into six phenotypes. After adjustment for age and sex, the frequencies of the VDR B/b, B/a, B/T, B/a/T in patients with hepatitis flare(s) were lower than those without (7 vs 20%, P0.009; 1 vs 9%, P0.004; 3 vs 10%, P0.007; 1 vs 9%, P0.005, respectively); in contrast, T/t, A/T, A/t, b/A/t were higher in flare(s) (8 vs 3%, P0.003; 49 vs 34%, P0.027; 2 vs 1%, P0.004; 0.5 vs 0%, P0.001, respectively). In addition, B/b, B/B, T/t, b/A, B/a, B/A, B/T, B/t, A/t, b/A/T, B/a/T, B/A/T, B/A/t, b/A/t were higher in patients positive for HBeAg. The distribution of VDR genotypes was comparable between patients with and without hepatocellular carcinoma (HCC). VDR gene polymorphisms are associated with distinct clinical phenotypes in Taiwanese HBV carriers but not with HCC development.

原文英語
頁(從 - 到)87-93
頁數7
期刊Genes and Immunity
11
發行號1
DOIs
出版狀態已發佈 - 一月 2010
對外發佈

ASJC Scopus subject areas

  • 免疫學
  • 遺傳學
  • 遺傳學(臨床)

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