Visfatin promotes the metastatic potential of chondrosarcoma cells by stimulating ap-1-dependent mmp-2 production in the mapk pathway

Shih Ya Hung, Chih Yang Lin, Cheng Chieh Yu, Hsien Te Chen, Ming Yu Lien, Yu Wen Huang, Yi Chin Fong, Ju Fang Liu, Shih Wei Wang, Wei Cheng Chen, Chih Hsin Tang

研究成果: 雜誌貢獻文章同行評審

摘要

Chondrosarcoma is a malignant bone tumor that is characterized by high metastatic potential and marked resistance to radiation and chemotherapy. The knowledge that adipokines facilitate the initiation, progression, metastasis, and treatment resistance of various tumors has driven several in vitro and in vivo investigations into the effects of adipokines resistin, leptin, and adiponectin upon the development and progression of chondrosarcomas. Another adipokine, visfatin, is known to regulate tumor progression and metastasis, although how this molecule may affect chondrosarcoma metastasis is unclear. Here, we found that visfatin facilitated cellular migration via matrix metalloproteinase-2 (MMP-2) production in human chondrosarcoma cells and overexpression of visfatin enhanced lung metastasis in a mouse model of chondrosarcoma. Visfatin-induced stimulation of MMP-2 synthesis and activation of the AP-1 transcription factor facilitated chondrosarcoma cell migration via the ERK, p38, and JNK signaling pathways. This evidence suggests that visfatin is worth targeting in the treatment of metastatic chondrosarcoma.

原文英語
文章編號8642
期刊International journal of molecular sciences
22
發行號16
DOIs
出版狀態已發佈 - 八月 2 2021

ASJC Scopus subject areas

  • 催化
  • 分子生物學
  • 光譜
  • 電腦科學應用
  • 物理與理論化學
  • 有機化學
  • 無機化學

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