Virus burden in long-term survivors of human immunodeficiency virus (hiv) infection is a determinant of anti-hiv cd8 + lymphocyte activity

Yin Johnhua Ferbas, Andrew H. Kaplan, Mary Ann Hausner, Lance E. Hultin, Jose L. Matud, Zhiyuan Liu, Dennis L. Panicali, Hong Nerng-Ho, Roger Detels, Janis V. Giorgi

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130 引文 斯高帕斯(Scopus)

摘要

Persons infected with human immunodeficiency virus (HIV) for >8 years were studied to delineate virologic and immunologic attributes of long-term survival. Whereas those with 300-700 CD4 + cells/μL often had circulating cytotoxic T lymphocytes (CTL) against HIV antigens, those with > 1000 CD4 + cells/μL did not. The subjects with > 1000 CD4 + cells/μL had low virus burden, low levels of Gag-specific CTL precursors, and minimal CD8 + cell activation. Overall, elevated levels of CD8 + cells, CD38 antigen expression on CD8 + cells, and anti-HIV functions were correlated with increased virus burden, provirus load, and HIV plasma RNA levels. A factor that suppressed HIV replication was spontaneously secreted from CD8 + cells of most subjects but not from those with high CD4 + cell counts. CD8 + cell activities, therefore, may reflect chronic viral stimulation of the immune system. Long-term survivors with high levels of CD4 + cells maintained control of viral replication but lacked the CD8 + cell activities.
原文英語
頁(從 - 到)329-339
頁數11
期刊Journal of Infectious Diseases
172
發行號2
DOIs
出版狀態已發佈 - 一月 1 1995
對外發佈Yes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Ferbas, Y. J., Kaplan, A. H., Hausner, M. A., Hultin, L. E., Matud, J. L., Liu, Z., Panicali, D. L., Nerng-Ho, H., Detels, R., & Giorgi, J. V. (1995). Virus burden in long-term survivors of human immunodeficiency virus (hiv) infection is a determinant of anti-hiv cd8 + lymphocyte activity. Journal of Infectious Diseases, 172(2), 329-339. https://doi.org/10.1093/infdis/172.2.329