Viral and host proteins involved in picornavirus life cycle

Jing Yi Lin, Tzu Chun Chen, Kuo Feng Weng, Shih Cheng Chang, Li Lien Chen, Shin Ru Shih

研究成果: 雜誌貢獻文章同行評審

124 引文 斯高帕斯(Scopus)

摘要

Picornaviruses cause several diseases, not only in humans but also in various animal hosts. For instance, human enteroviruses can cause hand-foot-and-mouth disease, herpangina, myocarditis, acute flaccid paralysis, acute hemorrhagic conjunctivitis, severe neurological complications, including brainstem encephalitis, meningitis and poliomyelitis, and even death. The interaction between the virus and the host is important for viral replication, virulence and pathogenicity. This article reviews studies of the functions of viral and host factors that are involved in the life cycle of picornavirus. The interactions of viral capsid proteins with host cell receptors is discussed first, and the mechanisms by which the viral and host cell factors are involved in viral replication, viral translation and the switch from translation to RNA replication are then addressed. Understanding how cellular proteins interact with viral RNA or viral proteins, as well as the roles of each in viral infection, will provide insights for the design of novel antiviral agents based on these interactions.

原文英語
文章編號103
期刊Journal of Biomedical Science
16
發行號1
DOIs
出版狀態已發佈 - 2009
對外發佈

ASJC Scopus subject areas

  • 臨床生物化學
  • 分子生物學
  • 細胞生物學
  • 生物化學(醫學)
  • 內分泌學、糖尿病和代謝
  • 藥學(醫學)

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