Vascular space occupancy-dependent functional MRI by tissue suppression

Changwei W. Wu, Kai Hsiang Chuang, Yau Yau Wai, Yung Liang Wan, Jyh Horng Chen, Ho Ling Liu

研究成果: 雜誌貢獻文章

11 引文 (Scopus)

摘要

Purpose: To measure the cerebral blood volume (CBV) dynamics during neural activation, a novel technique named vascular space occupancy (VASO)-based functional MRI (fMRI) was recently introduced for noninvasive CBV detection. However, its application is limited because of its low contrast-to-noise ratio (CNR) due to small signal change from the inverted blood. Materials and Methods: In this study a new approach-VASO with tissue suppression (VAST) - is proposed to enhance CNR. This technique is compared with VASO and blood oxygenation level-dependent (BOLD) fMRI in block-design and event-related visual experiments. Results: Based on acquired T1 maps, 75.3% of the activated pixels detected by VAST are located in the cortical gray matter. Temporal characteristics of functional responses obtained by VAST were consistent with that of VASO. Although the baseline signal was decreased by the tissue suppression, the CNR of VAST was about 43% higher than VASO. Conclusion: With the improved sensitivity, VAST fMRI provides a useful alternative for mapping the spatial/temporal features of regional CBV changes during brain activation. However, the technical imperfectness of VAST, such as the nonideal inversion efficiency and physiological contaminations, limits its application to precise CBV quantification.
原文英語
頁(從 - 到)219-226
頁數8
期刊Journal of Magnetic Resonance Imaging
28
發行號1
DOIs
出版狀態已發佈 - 七月 1 2008
對外發佈Yes

指紋

Blood Vessels
Magnetic Resonance Imaging
Noise
Cerebral Blood Volume
Brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

引用此文

Vascular space occupancy-dependent functional MRI by tissue suppression. / Wu, Changwei W.; Chuang, Kai Hsiang; Wai, Yau Yau; Wan, Yung Liang; Chen, Jyh Horng; Liu, Ho Ling.

於: Journal of Magnetic Resonance Imaging, 卷 28, 編號 1, 01.07.2008, p. 219-226.

研究成果: 雜誌貢獻文章

Wu, Changwei W. ; Chuang, Kai Hsiang ; Wai, Yau Yau ; Wan, Yung Liang ; Chen, Jyh Horng ; Liu, Ho Ling. / Vascular space occupancy-dependent functional MRI by tissue suppression. 於: Journal of Magnetic Resonance Imaging. 2008 ; 卷 28, 編號 1. 頁 219-226.
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