Vascular permeability precedes spontaneous intracerebral hemorrhage in stroke-prone spontaneously hypertensive rats

Jin Moo Lee, Guihua Zhai, Qingwei Liu, Ernesto R. Gonzales, Kejie Yin, Ping Yan, Chung Y. Hsu, Katie D. Vo, Weili Lin

研究成果: 雜誌貢獻文章同行評審

62 引文 斯高帕斯(Scopus)

摘要

BACKGROUND AND PURPOSE - Stroke-prone spontaneous hypertensive rats (SHRsp) fed a high-salt diet develop malignant hypertension, blood-brain barrier breakdown, and spontaneous intracerebral hemorrhage (ICH). The precise spatial and temporal relationship between these events has not been well-delineated. METHODS - Ten SHRsp male rats, fed a high-salt diet, were imaged weekly using MRI, starting at 12 weeks of age. T1-weighted (with and without Gd), T2-weighted, and T2* sequences were acquired. Permeability maps were calculated. RESULTS - Seven SHRsp rats had spontaneous ICH develop before death. Five of the 7 rats had focally increased vascular permeability at the site of the ICH; 3 of these rats had vascular permeability 1 to 2 weeks before spontaneous ICH. CONCLUSIONS - Salt-loaded SHRsp rats have increased vascular permeability up to 2 weeks before ICH, predicting hemorrhage both in space and time. These results suggest that hypertensive ICH is preceded by focal vasculopathy detectable by Gd leak.
原文英語
頁(從 - 到)3289-3291
頁數3
期刊Stroke
38
發行號12
DOIs
出版狀態已發佈 - 12月 2007

ASJC Scopus subject areas

  • 心臟病學與心血管醫學
  • 神經科學 (全部)

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