Validity of symptoms and radiographic features in predicting positive acid-fast bacilli smears in adolescents with tuberculosis

Kin Sun Wong, Y. C. Huang, S. H. Lai, C. Y. Chiu, Y. C. Huang, T. Y. Lin

研究成果: 雜誌貢獻文章

12 引文 (Scopus)

摘要

SETTING: A cohort of 78 adolescents was selected for evaluation with culture or histologically proven pulmonary tuberculosis (PTB) from a tertiary paediatric facility in northern Taiwan. OBJECTIVE: To assess the validity of clinical features and radiographic findings for predicting positive smears of acid-fast bacilli (AFB) in adolescents with PTB. DESIGN: A retrospective descriptive study of adolescents with a confirmed diagnosis of PTB. Clinical symptoms and chest radiographs were assessed. Univariate analysis identified risk factors suggestive of a positive AFB smear, and the adjusted odds ratio (aOR) for these features was calculated using logistic regression. RESULTS: Patients who were AFB smear-positive and those who were smear-negative differed significantly on univariate analysis (P < 0.05) with respect to chronic cough, haemoptysis, multilobar or superior segment of lower lobe involvement, cavitations or presence of pleural effusions. Logistic regression analysis revealed that risk factors of positive smear in adolescents with PTB were chronic cough >4 weeks (aOR 13.8, 95%CI 2.3-83.1), lower lobe involvement (aOR 12.6, 95%CI 1.2-134.8) and pulmonary cavitations (aOR 7.7, 95%CI 1.0-57.7). CONCLUSIONS: For adolescents with PTB, those suffering from chronic cough for >4 weeks, with involvement of the superior segment of the lower lobe or with cavitary lesions, have a greater likelihood of transmitting tuberculosis due to smear positivity.
原文英語
頁(從 - 到)155-159
頁數5
期刊International Journal of Tuberculosis and Lung Disease
14
發行號2
出版狀態已發佈 - 二月 2010
對外發佈Yes

指紋

Pulmonary Tuberculosis
Bacillus
Tuberculosis
Odds Ratio
Acids
Taiwan
Cough
Thorax
Retrospective Studies
Logistic Models
Pediatrics
Lung

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

引用此文

Validity of symptoms and radiographic features in predicting positive acid-fast bacilli smears in adolescents with tuberculosis. / Wong, Kin Sun; Huang, Y. C.; Lai, S. H.; Chiu, C. Y.; Huang, Y. C.; Lin, T. Y.

於: International Journal of Tuberculosis and Lung Disease, 卷 14, 編號 2, 02.2010, p. 155-159.

研究成果: 雜誌貢獻文章

@article{ee1f593b03fd4789a05a97056ada50c0,
title = "Validity of symptoms and radiographic features in predicting positive acid-fast bacilli smears in adolescents with tuberculosis",
abstract = "SETTING: A cohort of 78 adolescents was selected for evaluation with culture or histologically proven pulmonary tuberculosis (PTB) from a tertiary paediatric facility in northern Taiwan. OBJECTIVE: To assess the validity of clinical features and radiographic findings for predicting positive smears of acid-fast bacilli (AFB) in adolescents with PTB. DESIGN: A retrospective descriptive study of adolescents with a confirmed diagnosis of PTB. Clinical symptoms and chest radiographs were assessed. Univariate analysis identified risk factors suggestive of a positive AFB smear, and the adjusted odds ratio (aOR) for these features was calculated using logistic regression. RESULTS: Patients who were AFB smear-positive and those who were smear-negative differed significantly on univariate analysis (P < 0.05) with respect to chronic cough, haemoptysis, multilobar or superior segment of lower lobe involvement, cavitations or presence of pleural effusions. Logistic regression analysis revealed that risk factors of positive smear in adolescents with PTB were chronic cough >4 weeks (aOR 13.8, 95{\%}CI 2.3-83.1), lower lobe involvement (aOR 12.6, 95{\%}CI 1.2-134.8) and pulmonary cavitations (aOR 7.7, 95{\%}CI 1.0-57.7). CONCLUSIONS: For adolescents with PTB, those suffering from chronic cough for >4 weeks, with involvement of the superior segment of the lower lobe or with cavitary lesions, have a greater likelihood of transmitting tuberculosis due to smear positivity.",
keywords = "; tuberculosis, Adolescent, Cavitations, Chronic cough, Pulmonary, Smear AFB",
author = "Wong, {Kin Sun} and Huang, {Y. C.} and Lai, {S. H.} and Chiu, {C. Y.} and Huang, {Y. C.} and Lin, {T. Y.}",
year = "2010",
month = "2",
language = "English",
volume = "14",
pages = "155--159",
journal = "International Journal of Tuberculosis and Lung Disease",
issn = "1027-3719",
publisher = "International Union against Tubercul. and Lung Dis.",
number = "2",

}

TY - JOUR

T1 - Validity of symptoms and radiographic features in predicting positive acid-fast bacilli smears in adolescents with tuberculosis

AU - Wong, Kin Sun

AU - Huang, Y. C.

AU - Lai, S. H.

AU - Chiu, C. Y.

AU - Huang, Y. C.

AU - Lin, T. Y.

PY - 2010/2

Y1 - 2010/2

N2 - SETTING: A cohort of 78 adolescents was selected for evaluation with culture or histologically proven pulmonary tuberculosis (PTB) from a tertiary paediatric facility in northern Taiwan. OBJECTIVE: To assess the validity of clinical features and radiographic findings for predicting positive smears of acid-fast bacilli (AFB) in adolescents with PTB. DESIGN: A retrospective descriptive study of adolescents with a confirmed diagnosis of PTB. Clinical symptoms and chest radiographs were assessed. Univariate analysis identified risk factors suggestive of a positive AFB smear, and the adjusted odds ratio (aOR) for these features was calculated using logistic regression. RESULTS: Patients who were AFB smear-positive and those who were smear-negative differed significantly on univariate analysis (P < 0.05) with respect to chronic cough, haemoptysis, multilobar or superior segment of lower lobe involvement, cavitations or presence of pleural effusions. Logistic regression analysis revealed that risk factors of positive smear in adolescents with PTB were chronic cough >4 weeks (aOR 13.8, 95%CI 2.3-83.1), lower lobe involvement (aOR 12.6, 95%CI 1.2-134.8) and pulmonary cavitations (aOR 7.7, 95%CI 1.0-57.7). CONCLUSIONS: For adolescents with PTB, those suffering from chronic cough for >4 weeks, with involvement of the superior segment of the lower lobe or with cavitary lesions, have a greater likelihood of transmitting tuberculosis due to smear positivity.

AB - SETTING: A cohort of 78 adolescents was selected for evaluation with culture or histologically proven pulmonary tuberculosis (PTB) from a tertiary paediatric facility in northern Taiwan. OBJECTIVE: To assess the validity of clinical features and radiographic findings for predicting positive smears of acid-fast bacilli (AFB) in adolescents with PTB. DESIGN: A retrospective descriptive study of adolescents with a confirmed diagnosis of PTB. Clinical symptoms and chest radiographs were assessed. Univariate analysis identified risk factors suggestive of a positive AFB smear, and the adjusted odds ratio (aOR) for these features was calculated using logistic regression. RESULTS: Patients who were AFB smear-positive and those who were smear-negative differed significantly on univariate analysis (P < 0.05) with respect to chronic cough, haemoptysis, multilobar or superior segment of lower lobe involvement, cavitations or presence of pleural effusions. Logistic regression analysis revealed that risk factors of positive smear in adolescents with PTB were chronic cough >4 weeks (aOR 13.8, 95%CI 2.3-83.1), lower lobe involvement (aOR 12.6, 95%CI 1.2-134.8) and pulmonary cavitations (aOR 7.7, 95%CI 1.0-57.7). CONCLUSIONS: For adolescents with PTB, those suffering from chronic cough for >4 weeks, with involvement of the superior segment of the lower lobe or with cavitary lesions, have a greater likelihood of transmitting tuberculosis due to smear positivity.

KW - ; tuberculosis

KW - Adolescent

KW - Cavitations

KW - Chronic cough

KW - Pulmonary

KW - Smear AFB

UR - http://www.scopus.com/inward/record.url?scp=77049095203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77049095203&partnerID=8YFLogxK

M3 - Article

C2 - 20074405

AN - SCOPUS:77049095203

VL - 14

SP - 155

EP - 159

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

SN - 1027-3719

IS - 2

ER -