Validation of neuroimaging-based brain age gap as a mediator between modifiable risk factors and cognition

Chang Le Chen, Ming Che Kuo, Pin Yu Chen, Yu Hung Tung, Yung Chin Hsu, Chi Wen Christina Huang, Wing P. Chan, Wen Yih Isaac Tseng

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Neuroimaging-based brain age gap (BAG) is presumably a mediator linking modifiable risk factors to cognitive changes, but this has not been verified yet. To address this hypothesis, modality-specific brain age models were constructed and applied to a population-based cohort (N = 326) to estimate their BAG. Structural equation modeling was employed to investigate the mediation effect of BAG between modifiable risk factors (assessed by 2 cardiovascular risk scores) and cognitive functioning (examined by 4 cognitive assessments). The association between higher burden of modifiable risk factors and poorer cognitive functioning can be significantly mediated by a larger BAG (multimodal: p = 0.014, 40.8% mediation proportion; white matter-based: p = 0.023, 15.7% mediation proportion), which indicated an older brain. Subgroup analysis further revealed a steeper slope (p = 0.019) of association between cognitive functioning and multimodal BAG in the group of higher modifiable risks. The results confirm that BAG can serve as a mediating indicator linking risk loadings to cognitive functioning, implicating its potential in the management of cognitive aging and dementia.

原文英語
頁(從 - 到)61-72
頁數12
期刊Neurobiology of Aging
114
DOIs
出版狀態已發佈 - 6月 2022

ASJC Scopus subject areas

  • 神經科學 (全部)
  • 老化
  • 神經病學(臨床)
  • 發展生物學
  • 老年病學和老年學

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