Utilizing glycine N-methyltransferasegene knockout mice as a model for identification of missing proteins in hepatocellular carcinoma

Ming Hui Yang, Wan Jou Chen, Yaw Syan Fu, Bin Huang, Wan Chi Tsai, Yi Ming Arthur Chen, Po Chiao Lin, Cheng Hui Yuan, Yu Chang Tyan

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

Glycine N-methyltransferase is a tumor suppressor gene for hepatocellular carcinoma, which can activate DNA methylation by inducing the S-adenosylmethionine to S-adenosylhomocystine. Previous studies have indicated that the expression of Glycine N-methyltransferase is inhibited in hepatocellular carcinoma. To confirm and identify missing proteins, the pathologic analysis of the tumor-bearing mice will provide critical histologic information. Such a mouse model is applied as a screening tool for hepatocellular carcinoma as well as a strategy for missing protein discovery. In this study we designed an analysis platform using the human proteome atlas to compare the possible missing proteins to human whole chromosomes. This will integrate the information from animal studies to establish an optimal technique in the missing protein biomarker discovery.
原文英語
頁(從 - 到)442-452
頁數11
期刊Oncotarget
9
發行號1
DOIs
出版狀態已發佈 - 一月 1 2018
對外發佈Yes

ASJC Scopus subject areas

  • Oncology

指紋 深入研究「Utilizing glycine N-methyltransferasegene knockout mice as a model for identification of missing proteins in hepatocellular carcinoma」主題。共同形成了獨特的指紋。

引用此