Usp11 controls cortical neurogenesis and neuronal migration through Sox11 stabilization

Shang Yin Chiang, Hsin Chieh Wu, Shu Yu Lin, Hsin Yi Chen, Chia Fang Wang, Nai Hsing Yeh, Jou Ho Shih, Yi Shuian Huang, Hung Chih Kuo, Shen Ju Chou, Ruey Hwa Chen

研究成果: 雜誌貢獻文章同行評審

摘要

The role of protein stabilization in cortical development remains poorly understood. A recessive mutation in the USP11 gene is found in a rare neurodevelopmental disorder with intellectual disability, but its pathogenicity and molecular mechanism are unknown. Here, we show that mouse Usp11 is expressed highly in embryonic cerebral cortex, and Usp11 deficiency impairs layer 6 neuron production, delays late-born neuronal migration, and disturbs cognition and anxiety behaviors. Mechanistically, these functions are mediated by a previously unidentified Usp11 substrate, Sox11. Usp11 ablation compromises Sox11 protein accumulation in the developing cortex, despite the induction of Sox11 mRNA. The disease-associated Usp11 mutant fails to stabilize Sox11 and is unable to support cortical neurogenesis and neuronal migration. Our findings define a critical function of Usp11 in cortical development and highlight the importance of orchestrating protein stabilization mechanisms into transcription regulatory programs for a robust induction of cell fate determinants during early brain development.
原文英語
文章編號eabc6093
期刊Science advances
7
發行號7
DOIs
出版狀態已發佈 - 二月 12 2021

ASJC Scopus subject areas

  • General

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