Using the galectin-3 test to predict mortality in heart failure patients: A systematic review and meta-analysis

Yueh Sheng Chen; Weng Tein Gi; Tin Yun Liao; Meng Tse Gabriel Lee; Si Huei Lee; Wan Ting Hsu; Shy Shin Chang; Chien Chang Lee

doi:10.2217/bmm.15.121

Using the galectin-3 test to predict mortality in heart failure patients: A systematic review and meta-analysis

Yueh Sheng Chen, Weng Tein Gi, Tin Yun Liao, Meng Tse Gabriel Lee, Si Huei Lee, Wan Ting Hsu, Shy Shin Chang, Chien Chang Lee

研究成果: 雜誌貢獻 › 回顧型文獻 › 同行評審

22 引文斯高帕斯（Scopus）

摘要

Aim: Galectin-3 (Gal-3) is a new biomarker for assessing prognosis of heart failure (HF) patients. This systemic review and meta-analysis aims to examine Gal-3's ability in assessing prognosis of HF patients. Method: We searched MEDLINE and Embase up to November 2014. Test performance characteristics were summarized using forest plots and hierarchical summary receiver operating characteristic curves. Results: The diagnostic odds ratio of Gal-3 in predicting mortality in chronic HF patients was 2.36 (95% CI: 1.71-3.26) and 2.30 (95% CI: 1.76-3.01) in acute HF patients. Conclusion: Elevated levels of Gal-3 are associated with mortality in both acute and chronic HF patients. However, current evidence does not support sole use of Gal-3 for prognosis evaluation of HF patients.

原文	英語
頁（從 - 到）	329-342
頁數	14
期刊	Biomarkers in Medicine
卷	10
發行號	3
DOIs	https://doi.org/10.2217/bmm.15.121
出版狀態	已發佈 - 3月 2016
對外發佈	是

ASJC Scopus subject areas

藥物發現
臨床生物化學
生物化學（醫學）

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10.2217/bmm.15.121

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@article{c17942eed47e4472812d6f2894244857,

title = "Using the galectin-3 test to predict mortality in heart failure patients: A systematic review and meta-analysis",

abstract = "Aim: Galectin-3 (Gal-3) is a new biomarker for assessing prognosis of heart failure (HF) patients. This systemic review and meta-analysis aims to examine Gal-3's ability in assessing prognosis of HF patients. Method: We searched MEDLINE and Embase up to November 2014. Test performance characteristics were summarized using forest plots and hierarchical summary receiver operating characteristic curves. Results: The diagnostic odds ratio of Gal-3 in predicting mortality in chronic HF patients was 2.36 (95% CI: 1.71-3.26) and 2.30 (95% CI: 1.76-3.01) in acute HF patients. Conclusion: Elevated levels of Gal-3 are associated with mortality in both acute and chronic HF patients. However, current evidence does not support sole use of Gal-3 for prognosis evaluation of HF patients.",

keywords = "Galectin-3, heart failure, prognostic marker",

author = "Chen, {Yueh Sheng} and Gi, {Weng Tein} and Liao, {Tin Yun} and Lee, {Meng Tse Gabriel} and Lee, {Si Huei} and Hsu, {Wan Ting} and Chang, {Shy Shin} and Lee, {Chien Chang}",

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doi = "10.2217/bmm.15.121",

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T1 - Using the galectin-3 test to predict mortality in heart failure patients

T2 - A systematic review and meta-analysis

AU - Chen, Yueh Sheng

AU - Gi, Weng Tein

AU - Liao, Tin Yun

AU - Lee, Meng Tse Gabriel

AU - Lee, Si Huei

AU - Hsu, Wan Ting

AU - Chang, Shy Shin

AU - Lee, Chien Chang

PY - 2016/3

Y1 - 2016/3

N2 - Aim: Galectin-3 (Gal-3) is a new biomarker for assessing prognosis of heart failure (HF) patients. This systemic review and meta-analysis aims to examine Gal-3's ability in assessing prognosis of HF patients. Method: We searched MEDLINE and Embase up to November 2014. Test performance characteristics were summarized using forest plots and hierarchical summary receiver operating characteristic curves. Results: The diagnostic odds ratio of Gal-3 in predicting mortality in chronic HF patients was 2.36 (95% CI: 1.71-3.26) and 2.30 (95% CI: 1.76-3.01) in acute HF patients. Conclusion: Elevated levels of Gal-3 are associated with mortality in both acute and chronic HF patients. However, current evidence does not support sole use of Gal-3 for prognosis evaluation of HF patients.

AB - Aim: Galectin-3 (Gal-3) is a new biomarker for assessing prognosis of heart failure (HF) patients. This systemic review and meta-analysis aims to examine Gal-3's ability in assessing prognosis of HF patients. Method: We searched MEDLINE and Embase up to November 2014. Test performance characteristics were summarized using forest plots and hierarchical summary receiver operating characteristic curves. Results: The diagnostic odds ratio of Gal-3 in predicting mortality in chronic HF patients was 2.36 (95% CI: 1.71-3.26) and 2.30 (95% CI: 1.76-3.01) in acute HF patients. Conclusion: Elevated levels of Gal-3 are associated with mortality in both acute and chronic HF patients. However, current evidence does not support sole use of Gal-3 for prognosis evaluation of HF patients.

KW - Galectin-3

KW - heart failure

KW - prognostic marker

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Using the galectin-3 test to predict mortality in heart failure patients: A systematic review and meta-analysis

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