Using submicroporous Ta oxide coatings deposited by a simple hydrolysis-condensation process to increase the biological responses to Ti surface

Ying Sui Sun, Jean Heng Chang, Her Hsiung Huang

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)

摘要

This study used a simple hydrolysis-condensation process to prepare a tantalum pentoxide (Ta2O5) coating with submicroporous topography on a titanium (Ti) substrate. This coating is capable of enhancing biological responses. Characteristics of the surface coating, including morphology, composition, occurrence of functional groups, crystallographic structure, and degree of adherence, were analyzed. The release of Ti ions from the specimens in simulated blood plasma was also measured. The cytotoxicity of the specimens was determined according to ISO10993-5 specifications. We then evaluated biological responses, including fibronectin (FN) adsorption and human bone marrow mesenchymal stem cell (hBMSC) responses. Our results demonstrate that this simple hydrolysis-condensation process produced a negatively charged amorphous Ta2O5 coating with submicroporous topography and good adhesion to the Ti surface. Compared with an uncoated Ti surface, the Ta2O5 coating reduced the release of Ti ions and significantly enhanced FN adsorption and hBMSC responses, including cytoskeletal arrangement, cell adhesion, and cell proliferation. Thus, the proposed submicroporous Ta2O5 coating on a Ti surface has considerable potential for bone implant applications.
原文英語
頁(從 - 到)199-205
頁數7
期刊Surface and Coatings Technology
259
發行號PB
DOIs
出版狀態已發佈 - 1月 1 2014

ASJC Scopus subject areas

  • 化學 (全部)
  • 凝聚態物理學
  • 表面和介面
  • 表面、塗料和薄膜
  • 材料化學

指紋

深入研究「Using submicroporous Ta oxide coatings deposited by a simple hydrolysis-condensation process to increase the biological responses to Ti surface」主題。共同形成了獨特的指紋。

引用此