Using NF-κB as a molecular target for theranostics in radiation oncology research

Yu Chang Liu, I. Tsang Chiang, Fei Ting Hsu, Jeng Jong Hwang

研究成果: 雜誌貢獻回顧型文獻同行評審

28 引文 斯高帕斯(Scopus)

摘要

Resistance of cancer cells to chemotherapy and/or radiotherapy is a major challenge to current anticancer treatment. The NF-κB signaling pathway plays an important role in tumor development and progression, and results in unsatisfactory treatment outcome. Inhibition of the NF-κB signaling cascade may sensitize the resistant cancer cells to chemotherapy and/or radiotherapy. Here, the correlation of NF-κB molecules with carcinogenesis and tumor progression, along with its significance in clinical practice, is reviewed. The potential clinical application of NF-κB and its associated molecules as diagnostic and therapeutic targets is also discussed.
原文英語
頁(從 - 到)139-146
頁數8
期刊Expert Review of Molecular Diagnostics
12
發行號2
DOIs
出版狀態已發佈 - 3月 2012
對外發佈

ASJC Scopus subject areas

  • 分子醫學
  • 分子生物學
  • 遺傳學
  • 病理學與法醫學

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