Using conjunctival swab with polymerase chain reaction to aid diagnosis of cytomegalovirus retinitis in AIDS patients

Jorn Hon Liu, Wen-Ming Hsu, Wing Wai Wong, Jaang Jiun Wang, Wu Tse Liu, Cheng Yi Liu, Shih Hwa Chiou

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

Conjunctival swabs were used in combination with polymerase chain reactions (PCR) or virus culture to aid to confirm the diagnosis of cytomegalovirus (CMV) retinitis in AIDS patients. Based on ophthalmoscopic findings, 13 AIDS patients were diagnosed as having CMV retinitis and treated with systemic ganciclovir from January 1997 to December 1998. Nine of 13 AIDS patients with CMV retinitis were found to be positive for CMV DNA by using a conjunctival swab with PCR (CS-PCR). CMV was also isolated from the conjunctival swab culture in 2 AIDS patients with CMV retinitis. Following 1 month of systemic ganciclovir treatment, except for 1 patient who had disease progression and remained positive for CMV DNA by using CS-PCR, 12 patients were negative for CMV with a concordant lesion regression. Results of this study also indicate that this CS-PCR method is valuable for confirming the diagnosis of CMV retinitis and monitoring the ganciclovir effect on the treatment of CMV retinitis in AIDS patients. Copyright (C) 2000 S. Karger AG, Basel.

原文英語
頁(從 - 到)126-130
頁數5
期刊Ophthalmologica
214
發行號2
DOIs
出版狀態已發佈 - 一月 1 2000
對外發佈Yes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

指紋 深入研究「Using conjunctival swab with polymerase chain reaction to aid diagnosis of cytomegalovirus retinitis in AIDS patients」主題。共同形成了獨特的指紋。

引用此