Usefulness of plasma YKL-40 in management of community-acquired pneumonia severity in patients

Hsiang Ling Wang, Pei Ching Hsiao, Hsiu Ting Tsai, Chao Bin Yeh, Shun Fa Yang

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

摘要

Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in adult patients hospitalized with CAP. The ELISA was used to measure the plasma YKL-40 level from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls. The plasma YKL-40 levels were significantly increased in patients with CAP compared to normal controls. Moreover, the plasma concentration of YKL-40 correlated with the severity of CAP based on the pneumonia severity index (PSI) score (r = 0.630, p <0.001), the CURB-65 (confusion, uremia, respiratory rate, BP, age 65 years) score (r = 0.640, p <0.001), the Acute Physiology And Chronic Health Evaluation II (APACHE II) score (r = 0.539, p <0.001) and length of hospital stay (r = 0.321, p = 0.011), respectively. In conclusion, plasma YKL-40 may play a role in the diagnosis and clinical assessment of CAP severity, which could potentially guide the development of treatment strategies.

原文英語
頁(從 - 到)22817-22825
頁數9
期刊International Journal of Molecular Sciences
14
發行號11
DOIs
出版狀態已發佈 - 十一月 19 2013
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry

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