Usefulness of C-Reactive Protein and Interleukin-6 as Predictors of Outcomes in Patients With Chronic Obstructive Pulmonary Disease Receiving Pravastatin

Tsung-Ming Lee, Mei S. Lin, Nen Chung Chang

研究成果: 雜誌貢獻文章

116 引文 斯高帕斯(Scopus)


Inflammation is increased in chronic obstructive pulmonary disease (COPD) and plays a role in exercise intolerance. We investigated whether pravastatin administration is effective in improving exercise capacity in patients with COPD, and whether baseline or serial changes in high-sensitivity C-reactive protein (hs-CRP) over time are associated with corresponding changes in exercise capacity. In a randomized, double-blinded, and parallel design, 125 patients with clinically stable COPD were randomly assigned to receive placebo or pravastatin (40 mg/day) over a period of 6 months. Plasma hs-CRP levels were measured before randomization and during follow-up. Baseline characteristics were similar in the 2 groups. Exercise time remained stable throughout the study in the placebo group. Exercise time increased by 54% from 599 ± 323 seconds at baseline to 922 ± 328 seconds at the end (p
頁(從 - 到)530-535
期刊American Journal of Cardiology
出版狀態已發佈 - 二月 15 2008


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine