Usefulness of 201TL SPECT/CT relative to 18F-FDG PET/CT in detecting recurrent skull base nasopharyngeal carcinoma

Ruoh-Fang Yen, Lai-Lei Ting, Mei-Fang Cheng, Yen-Wen Wu, Kai-Yuan Tzen, Ruey-Long Hong

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)

摘要

BACKGROUND: This study was designed to compare (201)Tl single photon emission computed tomography (SPECT)/CT with 18-fluoro-2-deoxyglucose ((18)F-FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC).

METHODS: Twenty-seven patients were recruited. Both (201)Tl SPECT/CT and (18)F-FDG PET/CT for each patient were performed at least 4 months later after initial therapy.

RESULTS: The sensitivity and specificity for (201)Tl SPECT/CT were 66.7% and 100%, and those for (18)F-FDG PET/CT were 86.7% and 75.0%. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios.

CONCLUSION: (201)Tl SPECT/CT is as effective as (18)F-FDG PET/CT in detecting recurrent NPC. For intracranial recurrence, (201)Tl SPECT, because of its high intracranial lesion/background ratio, is probably better than (18)F-FDG PET.

原文英語
頁(從 - 到)717-24
頁數8
期刊Head and Neck
31
發行號6
DOIs
出版狀態已發佈 - 六月 2009
對外發佈Yes

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