Use of white blood cell counts to predict metabolic syndrome in the elderly: A 4 year longitudinal study

Ting Ting Chao, Chang Hsun Hsieh, Jiunn Diann Lin, Chung Ze Wu, Chun Hsien Hsu, Dee Pei, Yen Lin Chen, Yao Jen Liang, Jin Biou Chang

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Background: The white blood cell (WBC) count was one of the first inflammatory markers associated with metabolic syndrome (MetS). Recently, two longitudinal studies have demonstrated a cause and effect relationship between MetS and WBC counts among middle-aged adults. However, no study has used WBC cutoff values to predict MetS in the elderly.

Methods: Subjects who underwent routine health checkups, and were above 60 years of age, were enrolled. All subjects were followed-up until they developed MetS or until 4 years from the date of entry, whichever came earlier. Of the 4539 subjects eligible for enrollment, 3428 subjects comprised the study group and 1111 subjects comprised the validation group.

Results: WBC counts were significantly different between subjects with and without MetS in both genders. Using the ROC curve, WBC cutoff values of 5.7 × 103/l in males and 5.0 × 103/l in females were associated with the increased risk of developing MetS (all p values

Conclusions: The association between WBC count and MetS was gender specific. A WBC cutoff value greater than 5.0 103/l may predict the development of MetS in elderly women.

原文英語
頁(從 - 到)230-237
頁數8
期刊Aging Male
17
發行號4
DOIs
出版狀態已發佈 - 十二月 1 2014

指紋

Leukocyte Count
Longitudinal Studies
Leukocytes
ROC Curve
Health

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Medicine(all)

引用此文

Use of white blood cell counts to predict metabolic syndrome in the elderly : A 4 year longitudinal study. / Chao, Ting Ting; Hsieh, Chang Hsun; Lin, Jiunn Diann; Wu, Chung Ze; Hsu, Chun Hsien; Pei, Dee; Chen, Yen Lin; Liang, Yao Jen; Chang, Jin Biou.

於: Aging Male, 卷 17, 編號 4, 01.12.2014, p. 230-237.

研究成果: 雜誌貢獻文章

Chao, Ting Ting ; Hsieh, Chang Hsun ; Lin, Jiunn Diann ; Wu, Chung Ze ; Hsu, Chun Hsien ; Pei, Dee ; Chen, Yen Lin ; Liang, Yao Jen ; Chang, Jin Biou. / Use of white blood cell counts to predict metabolic syndrome in the elderly : A 4 year longitudinal study. 於: Aging Male. 2014 ; 卷 17, 編號 4. 頁 230-237.
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AU - Lin, Jiunn Diann

AU - Wu, Chung Ze

AU - Hsu, Chun Hsien

AU - Pei, Dee

AU - Chen, Yen Lin

AU - Liang, Yao Jen

AU - Chang, Jin Biou

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N2 - Background: The white blood cell (WBC) count was one of the first inflammatory markers associated with metabolic syndrome (MetS). Recently, two longitudinal studies have demonstrated a cause and effect relationship between MetS and WBC counts among middle-aged adults. However, no study has used WBC cutoff values to predict MetS in the elderly.Methods: Subjects who underwent routine health checkups, and were above 60 years of age, were enrolled. All subjects were followed-up until they developed MetS or until 4 years from the date of entry, whichever came earlier. Of the 4539 subjects eligible for enrollment, 3428 subjects comprised the study group and 1111 subjects comprised the validation group.Results: WBC counts were significantly different between subjects with and without MetS in both genders. Using the ROC curve, WBC cutoff values of 5.7 × 103/l in males and 5.0 × 103/l in females were associated with the increased risk of developing MetS (all p values Conclusions: The association between WBC count and MetS was gender specific. A WBC cutoff value greater than 5.0 103/l may predict the development of MetS in elderly women.

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