Use of soluble triggering receptor expressed on myeloid cells-1 in non-tuberculous mycobacterial lung disease

C. C. Shu, L. N. Lee, M. F. Wu, C. H. Lee, J. T. Wang, Jann Yuan Wang, C. J. Yu, L. N. Lee, P. C. Yang, W. J. Su, H. C. Lai, V. C. Wu, M. C. Yu

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

摘要

BACKGROUND: Serum biomarkers are rarely studied in patients with non-tuberculous mycobacterial lung disease (NTM-LD). OBJECTIVE: To investigate the role of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and other inflammatory markers in NTM-LD. DESIGN: From April 2009 to March 2010, patients with NTM culture-positive respiratory specimens who were clinically and radiographically suspected of NTM-LD were evaluated for serum levels of sTREM-1, C-reactive protein, procalcitonin and interferon-gamma. RESULTS: Of the 86 patients enrolled, 60 fulfilled the diagnosis of NTM-LD. Using the receiver-operating characteristics curve analysis, serum sTREM-1 had the highest discriminative power for NTM-LD and colonisation (area under the curve = 0.714). Using a cut-off value of 180 pg/ml, the sensitivity and specificity of sTREM-1 were respectively 58% and 89%. Logistic regression analysis revealed that Mycobacterium avium complex, M. kansasii, positive sputum acid-fast smear and higher serum sTREM-1 level were independent risk factors for NTM-LD. Age ≥65 years and higher serum sTREM-1 level were associated with worse 6-month survival. CONCLUSION: In patients with respiratory specimens that are culture-positive for NTM with clinical suspicion of NTM-LD, serum sTREM-1 level measurements may be helpful in diagnosing and predicting outcome for NTM-LD.

原文英語
頁(從 - 到)1415-1420
頁數6
期刊International Journal of Tuberculosis and Lung Disease
15
發行號10
DOIs
出版狀態已發佈 - 十月 2011
對外發佈Yes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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    Shu, C. C., Lee, L. N., Wu, M. F., Lee, C. H., Wang, J. T., Wang, J. Y., Yu, C. J., Lee, L. N., Yang, P. C., Su, W. J., Lai, H. C., Wu, V. C., & Yu, M. C. (2011). Use of soluble triggering receptor expressed on myeloid cells-1 in non-tuberculous mycobacterial lung disease. International Journal of Tuberculosis and Lung Disease, 15(10), 1415-1420. https://doi.org/10.5588/ijtld.10.0786