TY - JOUR
T1 - Use of low-dose topiramate in substance use disorder and bodyweight control
AU - Chiu, Yi Hang
AU - Lee, Ting Hui
AU - Shen, Winston W.
PY - 2007/12
Y1 - 2007/12
N2 - In recent years topiramate has been used for psychiatric patients, mainly for controlling substance use and food intake. A total of 46 patients who received topiramate treatment during the study period were identified from a computer database. Nineteen had received topiramate for at least 1 month. Twelve patients received topiramate for anticraving effects (alcohol, n = 9; heroin/amphetamine, n = 1; meperidine, n = 1; and nicotine, n = 1). On an average dosage of 112.5 mg/day, nine of the 12 patients (excluding three alcoholic patients) achieved complete or partial remission from the substance use disorders. The present results show that six of the nine patients achieved full or partial remission from alcohol use disorder on a dosage of 100 mg/day. Topiramate was also used to control seven patients' bodyweight (mean bodyweight change, 1.53 kg). Four of them achieved bodyweight loss in the 1-month follow up, with an average change of 2.65 kg. Based on the present findings topiramate
AB - In recent years topiramate has been used for psychiatric patients, mainly for controlling substance use and food intake. A total of 46 patients who received topiramate treatment during the study period were identified from a computer database. Nineteen had received topiramate for at least 1 month. Twelve patients received topiramate for anticraving effects (alcohol, n = 9; heroin/amphetamine, n = 1; meperidine, n = 1; and nicotine, n = 1). On an average dosage of 112.5 mg/day, nine of the 12 patients (excluding three alcoholic patients) achieved complete or partial remission from the substance use disorders. The present results show that six of the nine patients achieved full or partial remission from alcohol use disorder on a dosage of 100 mg/day. Topiramate was also used to control seven patients' bodyweight (mean bodyweight change, 1.53 kg). Four of them achieved bodyweight loss in the 1-month follow up, with an average change of 2.65 kg. Based on the present findings topiramate
KW - Alcohol dependence
KW - Bodyweight
KW - Substance dependence
KW - Substance use disorder
KW - Topiramate
UR - http://www.scopus.com/inward/record.url?scp=36849030836&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36849030836&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1819.2007.01718.x
DO - 10.1111/j.1440-1819.2007.01718.x
M3 - Article
C2 - 18081623
AN - SCOPUS:36849030836
VL - 61
SP - 630
EP - 633
JO - Psychiatry and Clinical Neurosciences
JF - Psychiatry and Clinical Neurosciences
SN - 1323-1316
IS - 6
ER -