摘要

Skeletal muscle injuries are the most common sports-related injuries and present a challenge in primary care and sports medicine. When a skeletal muscle is injured, satellite cells are activated and inflammatory cells migrate to the injury site. Complete recovery from the injury is compromised due to the development of fibrosis. To minimize the disability and enhance full functional recovery after skeletal muscle injuries, growth factors acting on satellite cells and inflammatory cells were developed to promote the regeneration of injured skeletal muscle. To improve injured muscle to recover better or faster, several biological growth factors had been developed, such as exogenous growth factors which would promote healing of injured muscle fibers, the inhibition of which would block the muscle fibrosis. Drugs that inhibit TGF-ß (transforming growth factor-ß) had been developed for clinical use with some good results. More clinical trial was needed for the development of drugs that promote the regeneration of injured skeletal muscle.

原文英語
主出版物標題Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation, Second Edition
發行者Springer Berlin Heidelberg
頁面2335-2345
頁數11
ISBN(列印)9783642365690, 9783642365683
DOIs
出版狀態已發佈 - 一月 1 2015

指紋

Intercellular Signaling Peptides and Proteins
Skeletal Muscle
Muscles
Wounds and Injuries
Regeneration
Fibrosis
Athletic Injuries
Sports Medicine
Biological Factors
Transforming Growth Factors
Pharmaceutical Preparations
Primary Health Care
Clinical Trials

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Chen, C. H., Lee, C. H., & Chang, C. H. (2015). Usage of growth factors in acute muscle injuries. 於 Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation, Second Edition (頁 2335-2345). Springer Berlin Heidelberg. https://doi.org/10.1007/10.1007/978-3-642-36569-0_187

Usage of growth factors in acute muscle injuries. / Chen, Chih Hwa; Lee, Chian Her; Chang, Chih Hsiang.

Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation, Second Edition. Springer Berlin Heidelberg, 2015. p. 2335-2345.

研究成果: 書貢獻/報告類型章節

Chen, CH, Lee, CH & Chang, CH 2015, Usage of growth factors in acute muscle injuries. 於 Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation, Second Edition. Springer Berlin Heidelberg, 頁 2335-2345. https://doi.org/10.1007/10.1007/978-3-642-36569-0_187
Chen CH, Lee CH, Chang CH. Usage of growth factors in acute muscle injuries. 於 Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation, Second Edition. Springer Berlin Heidelberg. 2015. p. 2335-2345 https://doi.org/10.1007/10.1007/978-3-642-36569-0_187
Chen, Chih Hwa ; Lee, Chian Her ; Chang, Chih Hsiang. / Usage of growth factors in acute muscle injuries. Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation, Second Edition. Springer Berlin Heidelberg, 2015. 頁 2335-2345
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