摘要

Skeletal muscle injuries are the most common sports-related injuries and present a challenge in primary care and sports medicine. When a skeletal muscle is injured, satellite cells are activated and inflammatory cells migrate to the injury site. Complete recovery from the injury is compromised due to the development of fibrosis. To minimize the disability and enhance full functional recovery after skeletal muscle injuries, growth factors acting on satellite cells and inflammatory cells were developed to promote the regeneration of injured skeletal muscle. To improve injured muscle to recover better or faster, several biological growth factors had been developed, such as exogenous growth factors which would promote healing of injured muscle fibers, the inhibition of which would block the muscle fibrosis. Drugs that inhibit TGF-ß (transforming growth factor-ß) had been developed for clinical use with some good results. More clinical trial was needed for the development of drugs that promote the regeneration of injured skeletal muscle.

原文英語
主出版物標題Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation, Second Edition
發行者Springer Berlin Heidelberg
頁面2335-2345
頁數11
ISBN(列印)9783642365690, 9783642365683
DOIs
出版狀態已發佈 - 一月 1 2015

ASJC Scopus subject areas

  • Medicine(all)

指紋 深入研究「Usage of growth factors in acute muscle injuries」主題。共同形成了獨特的指紋。

  • 引用此

    Chen, C. H., Lee, C. H., & Chang, C. H. (2015). Usage of growth factors in acute muscle injuries. 於 Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation, Second Edition (頁 2335-2345). Springer Berlin Heidelberg. https://doi.org/10.1007/10.1007/978-3-642-36569-0_187