Uropathogenic Escherichia coli causes cortical tubular necrotic cell death and the release of macrophage migration inhibitory factor

Ming-Yuan Hong, Chin-Chung Tseng, Chia-Chang Chuang, Chia-Ling Chen, Yu-Huei Lin, Chia-Yuan Hsieh, Yu-Tzu Chang, Chung Hsi Hsing, Kwang-Yu Chang, Chiou Feng Lin

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

The macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, is deregulated in acute kidney injury (AKI) through an unknown mechanism. In the present study, we used a previously described mouse model of ascending urinary tract infection in which uropathogenic Escherichia coli (UPEC) were transurethrally inoculated to induce kidney infections. Here, we show that urinary MIF was upregulated during AKI while MIF was abundantly expressed in the renal cortical tubules and that UPEC infection caused a decrease in tubular MIF. Infections with UPEC in vitro caused MIF release in a cell type-dependent manner, which was independent of receptor-mediated internalization, signal transduction, and transcription. Indeed, UPEC infection-induced necrotic cell death in vitro and in vivo correlated with extracellular acidification and processed MIF secretion. These data suggest that MIF is released by necrotic renal cortical tubular cells during UPEC infection.
原文英語
頁(從 - 到)945-952
頁數8
期刊Cytokine
61
發行號3
DOIs
出版狀態已發佈 - 三月 2013

ASJC Scopus subject areas

  • 免疫學和過敏
  • 免疫學
  • 生物化學
  • 血液學
  • 分子生物學

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