摘要
The receptor for urokinase-type plasminogen activator (uPAR/CD87) is a 35-65 K Mr glycoprotein composed of 283 amino acid residues. It is anchored to the plasma membrane by a glycosyl phosphatidylinositol (GPI)-linkage. Binding of urokinase-type plasminogen activator (uPA) to its receptor, uPAR, regulates cellular adhesion, migration, and tumor cell invasion. It has been proposed that uPAR forms cis-interactions with integrins as an associated protein, and transduces proliferative or migratory signals to cells upon binding of uPA. However, it is still unclear how GPI-anchored uPAR, which lacks a transmembrane structure, mediates signal transduction. We found that recombinant soluble human uPAR (suPAR) synthesized in CHO cells specifically binds to recombinant human integrins a4βl,
原文 | 英語 |
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期刊 | Blood |
卷 | 96 |
發行號 | 11 PART I |
出版狀態 | 已發佈 - 2000 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 血液學