Urinary cell-free DNA as a potential tumor marker for bladder cancer

Hsueh Wei Chang, K. H. Tsui, L. C. Shen, H. W. Huang, S. N. Wang, Phei Lang Chang

研究成果: 雜誌貢獻文章同行評審

31 引文 斯高帕斯(Scopus)

摘要

The objective was to assess the possibility of measuring urine creatinine (UCr)-adjusted urinary cell-free (ucf) DNA concentration as a noninvasive screening tool for bladder cancer. Using PicoGreen-based detection, the ucf-DNA/UCr concentration was quantified in urine supernatant specimens from 46 bladder cancer patients and 98 controls and compared to 400-bp real-time PCR-based detection, which detected the amplification of 400-bp β-actin (named 400-bp ucf-DNA/UCr). The mean concentrations for both PicoGreen and 400-bp ucf-DNA (ng/mL)/UCr (mg/dL) were significantly higher in bladder cancer patients than in controls: 15.28 vs 6.68 (p
原文英語
頁(從 - 到)287-294
頁數8
期刊International Journal of Biological Markers
22
發行號4
DOIs
出版狀態已發佈 - 2007
對外發佈

ASJC Scopus subject areas

  • 病理學與法醫學
  • 腫瘤科
  • 臨床生物化學
  • 癌症研究

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