Urinary arsenic profile affects the risk of urothelial carcinoma even at low arsenic exposure

Yeong Shiau Pu, Shu Mei Yang, Yung Kai Huang, Chi Jung Chung, Steven K. Huang, Wen-Hsiang Chiou, Mo Hsiung Yang, Chien Jen Chen, Yu Mei Hsueh

研究成果: 雜誌貢獻文章同行評審

114 引文 斯高帕斯(Scopus)

摘要

Arsenic exposure is associated with an increased risk of urothelial carcinoma (UC). To explore the association between individual risk and urinary arsenic profile in subjects without evident exposure, 177 UC cases and 313 age-matched controls were recruited between September 2002 and May 2004 for a case-control study. Urinary arsenic species including the following three categories, inorganic arsenic (AsIII + AsV), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV), were determined with high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Arsenic methylation profile was assessed by percentages of various arsenic species in the sum of the three categories measured. The primary methylation index (PMI) was defined as the ratio between MMAV and inorganic arsenic. Secondary methylation index (SMI) was determined as the ratio between DMAV and MMAV. Smoking is associated with a significant risk of UC in a dose-dependent manner. After multivariate adjustment, UC cases had a significantly higher sum of all the urinary species measured, higher percent MMAV, lower percent DMAV, higher PMI and lower SMI values compared with controls. Smoking interacts with the urinary arsenic profile in modifying the UC risk. Differential carcinogenic effects of the urinary arsenic profile, however, were seen more prominently in non-smokers than in smokers, suggesting that smoking is not the only major environmental source of arsenic contamination since the UC risk differs in non-smokers. Subjects who have an unfavorable urinary arsenic profile have an increased UC risk even at low exposure levels.
原文英語
頁(從 - 到)99-106
頁數8
期刊Toxicology and Applied Pharmacology
218
發行號2
DOIs
出版狀態已發佈 - 1月 15 2007

ASJC Scopus subject areas

  • 藥理
  • 毒理學

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