Uric acid concentration as a risk marker for blood pressure progression and incident hypertension: A Chinese cohort study

Tsan Yang, Chi Hong Chu, Chyi Huey Bai, San Lin You, Yu Ching Chou, Lee Ching Hwang, Kuo Liong Chien, Ta Chen Su, Chin Hsiao Tseng, Chien An Sun

研究成果: 雜誌貢獻文章同行評審

42 引文 斯高帕斯(Scopus)

摘要

Objective: Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events. We aimed to explore the relationship in a comprehensive Chinese cohort. Methods: Participants in the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia (TwSHHH) who were free of hypertension at baseline recruitment in 2002 (n= 3257) were evaluated for the longitudinal association between baseline SUA and blood pressure progression (BPP) and incident hypertension. Results: During a mean follow-up of 5.41 years, 1119 persons (34.3%) had experienced progression to a higher blood pressure stage and 496 persons (15.2%) had developed hypertension. In multivariate analyses, the adjusted hazard ratios (HRs) [95% confidence intervals (CIs)] comparing the highest and lowest SUA quartiles were 1.78 (1.11-2.02, P for trend.004) for BPP and 1.68 (1.23-2.04, P for trend.028) for incident hypertension. The positively graded relationships between SUA concentration and blood pressure outcomes were observed in both males and females. More interestingly, a statistically significant trend for increasing risk of BPP and incident hypertension across SUA quartiles was most pronounced in participants with abdominal obesity. Conclusion: We concluded that SUA level was an independent predictor of blood pressure progression and incident hypertension in a Chinese population.

原文英語
頁(從 - 到)1747-1755
頁數9
期刊Metabolism: Clinical and Experimental
61
發行號12
DOIs
出版狀態已發佈 - 十二月 2012

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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