摘要
Objective: Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events. We aimed to explore the relationship in a comprehensive Chinese cohort. Methods: Participants in the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia (TwSHHH) who were free of hypertension at baseline recruitment in 2002 (n= 3257) were evaluated for the longitudinal association between baseline SUA and blood pressure progression (BPP) and incident hypertension. Results: During a mean follow-up of 5.41 years, 1119 persons (34.3%) had experienced progression to a higher blood pressure stage and 496 persons (15.2%) had developed hypertension. In multivariate analyses, the adjusted hazard ratios (HRs) [95% confidence intervals (CIs)] comparing the highest and lowest SUA quartiles were 1.78 (1.11-2.02, P for trend.004) for BPP and 1.68 (1.23-2.04, P for trend.028) for incident hypertension. The positively graded relationships between SUA concentration and blood pressure outcomes were observed in both males and females. More interestingly, a statistically significant trend for increasing risk of BPP and incident hypertension across SUA quartiles was most pronounced in participants with abdominal obesity. Conclusion: We concluded that SUA level was an independent predictor of blood pressure progression and incident hypertension in a Chinese population.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 1747-1755 |
| 頁數 | 9 |
| 期刊 | Metabolism: Clinical and Experimental |
| 卷 | 61 |
| 發行號 | 12 |
| DOIs | |
| 出版狀態 | 已發佈 - 十二月 2012 |
指紋
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
引用此文
Uric acid concentration as a risk marker for blood pressure progression and incident hypertension : A Chinese cohort study. / Yang, Tsan; Chu, Chi Hong; Bai, Chyi Huey; You, San Lin; Chou, Yu Ching; Hwang, Lee Ching; Chien, Kuo Liong; Su, Ta Chen; Tseng, Chin Hsiao; Sun, Chien An.
於: Metabolism: Clinical and Experimental, 卷 61, 編號 12, 12.2012, p. 1747-1755.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Uric acid concentration as a risk marker for blood pressure progression and incident hypertension
T2 - A Chinese cohort study
AU - Yang, Tsan
AU - Chu, Chi Hong
AU - Bai, Chyi Huey
AU - You, San Lin
AU - Chou, Yu Ching
AU - Hwang, Lee Ching
AU - Chien, Kuo Liong
AU - Su, Ta Chen
AU - Tseng, Chin Hsiao
AU - Sun, Chien An
PY - 2012/12
Y1 - 2012/12
N2 - Objective: Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events. We aimed to explore the relationship in a comprehensive Chinese cohort. Methods: Participants in the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia (TwSHHH) who were free of hypertension at baseline recruitment in 2002 (n= 3257) were evaluated for the longitudinal association between baseline SUA and blood pressure progression (BPP) and incident hypertension. Results: During a mean follow-up of 5.41 years, 1119 persons (34.3%) had experienced progression to a higher blood pressure stage and 496 persons (15.2%) had developed hypertension. In multivariate analyses, the adjusted hazard ratios (HRs) [95% confidence intervals (CIs)] comparing the highest and lowest SUA quartiles were 1.78 (1.11-2.02, P for trend.004) for BPP and 1.68 (1.23-2.04, P for trend.028) for incident hypertension. The positively graded relationships between SUA concentration and blood pressure outcomes were observed in both males and females. More interestingly, a statistically significant trend for increasing risk of BPP and incident hypertension across SUA quartiles was most pronounced in participants with abdominal obesity. Conclusion: We concluded that SUA level was an independent predictor of blood pressure progression and incident hypertension in a Chinese population.
AB - Objective: Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events. We aimed to explore the relationship in a comprehensive Chinese cohort. Methods: Participants in the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia (TwSHHH) who were free of hypertension at baseline recruitment in 2002 (n= 3257) were evaluated for the longitudinal association between baseline SUA and blood pressure progression (BPP) and incident hypertension. Results: During a mean follow-up of 5.41 years, 1119 persons (34.3%) had experienced progression to a higher blood pressure stage and 496 persons (15.2%) had developed hypertension. In multivariate analyses, the adjusted hazard ratios (HRs) [95% confidence intervals (CIs)] comparing the highest and lowest SUA quartiles were 1.78 (1.11-2.02, P for trend.004) for BPP and 1.68 (1.23-2.04, P for trend.028) for incident hypertension. The positively graded relationships between SUA concentration and blood pressure outcomes were observed in both males and females. More interestingly, a statistically significant trend for increasing risk of BPP and incident hypertension across SUA quartiles was most pronounced in participants with abdominal obesity. Conclusion: We concluded that SUA level was an independent predictor of blood pressure progression and incident hypertension in a Chinese population.
KW - Abdominal obesity
KW - Longitudinal study
KW - Serum uric acid
UR - http://www.scopus.com/inward/record.url?scp=84869509279&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869509279&partnerID=8YFLogxK
U2 - 10.1016/j.metabol.2012.05.006
DO - 10.1016/j.metabol.2012.05.006
M3 - Article
C2 - 22656272
AN - SCOPUS:84869509279
VL - 61
SP - 1747
EP - 1755
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 12
ER -