Upregulation of fecal cytokeratin 19 is associated with prognosis in older colorectal cancer patients

Ruey Neng Yang, Shung Haur Yang, Chun Chao Chang, Chih Cheng Chien, Shiann Pan, Chi Jung Huang

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)

摘要

The upregulation of fecal cytokeratin 19 (CK19) correlates with age and metastatic status in human colorectal cancer (CRC). To further explore its clinical significance in older patients (>60 years), their fecal CK19 was measured by quantitative reverse transcription-polymerase chain reaction. Differences in CK19 transcripts were compared using the nonparametric Mann-Whitney U test. Clinical significance was assessed with the chi-squared test and a binary logistic regression model. The association between overall survival and expressions of fecal CK19 in combination with other serum markers, carcinoembryonic antigen and carbohydrate antigen 19-9 (CA19-9), was evaluated using the Kaplan-Meier method. In these older groups, CRC patients had significantly higher median fecal CK19 expression (p=0.006) than controls. The highest risk of CRC (odds ratio, 5.8; 95% confidence interval, 2.3-14.7; p
原文英語
頁(從 - 到)703-708
頁數6
期刊Genetic Testing and Molecular Biomarkers
14
發行號5
DOIs
出版狀態已發佈 - 十月 1 2010

ASJC Scopus subject areas

  • 遺傳學(臨床)

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