Up-regulation of connective tissue growth factor in hyperoxia-induced lung fibrosis

Chung Ming Chen, Leng Fang Wang, Hsiu Chu Chou, Yaw Dong Lang, Yi Ping Lai

研究成果: 雜誌貢獻文章

62 引文 斯高帕斯(Scopus)

摘要

Pulmonary oxygen toxicity plays an important role in the lung injury process that leads to the development of bronchopulmonary dysplasia. Connective tissue growth factor (CTGF) is a fibroblast mitogen and promoter of collagen deposition. We investigated the effects of postnatal hyperoxia on lung collagen and CTGF expression in rats. Rat pups were exposed to 7 d of >95% O2 and a further 3 wk of 60% O2. CTGF mRNA and protein expression increased after hyperoxia treatment, and the values were significantly higher in hyperoxia-exposed rats on postnatal d 7 and 14. Lung collagen levels increased as rats aged, and the values were comparable between room air-exposed and hyperoxia-exposed rats on postnatal d 7 and 14 and were significantly higher in hyperoxia-exposed rats on postnatal d 21 and 28. Increases in CTGF mRNA and protein expressions preceded the onset of increased lung collagen. These data demonstrate that CTGF is up-regulated at time points preceding the fibrotic phase of the lung injury adding credence to the hypothesis that CTGF seems to be involved in the pathogenesis of hyperoxia-induced lung fibrosis and an anti-CTGF strategy might attenuate hyperoxia-induced lung fibrosis.
原文英語
頁(從 - 到)128-133
頁數6
期刊Pediatric Research
62
發行號2
DOIs
出版狀態已發佈 - 八月 2007

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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