Unusual clonal evolution in a case of chronic myelogenous leukemia

J. Whang Peng, S. Broder, E. Lee, R. C. Young

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)


Several unusual cytogenetic changes have occurred during the evolution of chronic myelogenous leukemia in a 32 year old white male with this disease for 8 years. The first appearance of a hypodiploid cell line containing a dicentric marker occurred 2 years after diagnosis and this line was eliminated by several courses of therapy with hydroxyurea. A second clone, which had a partial deletion of the long arm of one of the number 8 chromosomes (8q-) was noted a year later, but this line is refractory to intensive combination chemotherapy.
頁(從 - 到)345-354
期刊Acta Haematologica
出版狀態已發佈 - 十二月 1 1976

ASJC Scopus subject areas

  • Medicine(all)
  • Hematology

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