Unstable sleep and higher sympathetic activity during late-sleep periods of rats: Implication for late-sleep-related higher cardiovascular events

Terry B J Kuo, Chun Ting Lai, Chun Yu Chen, Guo She Lee, Cheryl C H Yang

研究成果: 雜誌貢獻文章

10 引文 (Scopus)

摘要

We proposed that the higher incidence of sleep fragmentation, sympathovagal imbalance and baroreceptor reflex impairment during quiet sleep may play a critical role in late-sleep-related cardiovascular events. Polysomnographic recording was performed through wireless transmission using freely moving Wistar-Kyoto rats over 24h. The low-frequency power of arterial pressure variability was quantified to provide an index of vascular sympathetic activity. Spontaneous baroreflex sensitivity was assessed by slope of arterial pressure-RR linear regression. As compared with early-light period (Zeitgeber time 0-6h), rats during the late-light period (Zeitgeber time 6-12h) showed lower accumulated quiet sleep time and higher paradoxical sleep time; furthermore, during quiet sleep, the rats showed a lower δ% of electroencephalogram, more incidents of interruptions, higher σ% and higher β% of electroencephalogram, raised low-frequency power of arterial pressure variability value and lower baroreflex sensitivity parameters. During the light period, low-frequency power of arterial pressure variability during quiet sleep had a negative correlation with accumulated quiet sleep time and δ% of electroencephalogram, while it also had a positive correlation with σ% and β% of electroencephalogram and interruption events. However, late-sleep-related raised sympathetic activity and sleep fragmentation diminished when an α1-adrenoceptor antagonist was given to the rats. Our results suggest that the higher incidence of sleep fragmentation and sympathovagal imbalance during quiet sleep may play a critical role in late-sleep-related cardiovascular events. Such sleep fragmentation is coincident with an impairment of baroreflex sensitivity, and is mediated via α1-adernoceptors.
原文英語
頁(從 - 到)108-118
頁數11
期刊Journal of Sleep Research
22
發行號1
DOIs
出版狀態已發佈 - 二月 2013
對外發佈Yes

指紋

Sleep
Sleep Deprivation
Baroreflex
Electroencephalography
Arterial Pressure
Light
Inbred WKY Rats
Incidence
REM Sleep
Adrenergic Receptors
Blood Vessels
Linear Models
Power (Psychology)

ASJC Scopus subject areas

  • Medicine(all)
  • Cognitive Neuroscience
  • Behavioral Neuroscience

引用此文

Unstable sleep and higher sympathetic activity during late-sleep periods of rats : Implication for late-sleep-related higher cardiovascular events. / Kuo, Terry B J; Lai, Chun Ting; Chen, Chun Yu; Lee, Guo She; Yang, Cheryl C H.

於: Journal of Sleep Research, 卷 22, 編號 1, 02.2013, p. 108-118.

研究成果: 雜誌貢獻文章

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AB - We proposed that the higher incidence of sleep fragmentation, sympathovagal imbalance and baroreceptor reflex impairment during quiet sleep may play a critical role in late-sleep-related cardiovascular events. Polysomnographic recording was performed through wireless transmission using freely moving Wistar-Kyoto rats over 24h. The low-frequency power of arterial pressure variability was quantified to provide an index of vascular sympathetic activity. Spontaneous baroreflex sensitivity was assessed by slope of arterial pressure-RR linear regression. As compared with early-light period (Zeitgeber time 0-6h), rats during the late-light period (Zeitgeber time 6-12h) showed lower accumulated quiet sleep time and higher paradoxical sleep time; furthermore, during quiet sleep, the rats showed a lower δ% of electroencephalogram, more incidents of interruptions, higher σ% and higher β% of electroencephalogram, raised low-frequency power of arterial pressure variability value and lower baroreflex sensitivity parameters. During the light period, low-frequency power of arterial pressure variability during quiet sleep had a negative correlation with accumulated quiet sleep time and δ% of electroencephalogram, while it also had a positive correlation with σ% and β% of electroencephalogram and interruption events. However, late-sleep-related raised sympathetic activity and sleep fragmentation diminished when an α1-adrenoceptor antagonist was given to the rats. Our results suggest that the higher incidence of sleep fragmentation and sympathovagal imbalance during quiet sleep may play a critical role in late-sleep-related cardiovascular events. Such sleep fragmentation is coincident with an impairment of baroreflex sensitivity, and is mediated via α1-adernoceptors.

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