Unique variants of human papillomavirus genotypes 52 and 58 and risk of cervical neoplasia

Ya Ju Chang, Hui Chi Chen, Bor Heng Lee, San Lin You, Ching Yu Lin, Mei Hung Pan, Yi Chun Chou, Chang Yao Hsieh, Yi Ming A Chen, Yu Juen Cheng, Chien Jen Chen

研究成果: 雜誌貢獻文章

34 引文 (Scopus)

摘要

Human papillomavirus (HPV) 52 and 58 are oncogenic HPV types prevalent in Asia. Our study aims to explore intratypic variants of HPV 52 and 58 in Taiwan. A total of 11,923 women were enrolled from seven townships in 1991-1992. HPV DNA in their cervical cells was detected and typed by EasyChip® HPV blot. Among 424 participants infected with HPV 52 and/or 58, nucleotide variations were determined in cervical cell samples of 406 participants by the polymerase chain reaction sequencing of the long control region, E6 and E7 genes. Nonprototype-like variants including lineages B and C were detected in 278 (99.3%) of 280 HPV 52 samples. The prototype and prototype-like group (lineage A) of HPV58 was found in 132 (98.5%) of 134 HPV 58 samples, with sublineage A1, A2 and A3 variant in 14.2, 27.6 and 56.7%, respectively. Among women infected with single HPV 52 type, the C variant (vs. B variant) was associated with an increased prevalence of cytologically diagnosed high-grade squamous intraepithelial lesion or worse lesions showing an age-adjusted odds ratio (95% confidence interval, CI) of 5.2 (1.0-27.6) and an increased prevalence of histologically confirmed high-grade cervical intraepithelial neoplasia or more severe lesions with an age-adjusted odds ratio (95% CI) of 7.6 (1.3-43.8). It was concluded that frequency distributions of HPV 52 and 58 variants in Taiwan were different from those in European and American populations. The association between C variant of HPV 52 and prevalence of cervical neoplasia needs further validation.
原文英語
頁(從 - 到)965-973
頁數9
期刊International Journal of Cancer
129
發行號4
DOIs
出版狀態已發佈 - 八月 15 2011

指紋

Genotype
Neoplasms
Taiwan
Odds Ratio
Confidence Intervals
Cervical Intraepithelial Neoplasia
varespladib methyl
Nucleotides
Polymerase Chain Reaction
DNA
Population
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

引用此文

Unique variants of human papillomavirus genotypes 52 and 58 and risk of cervical neoplasia. / Chang, Ya Ju; Chen, Hui Chi; Lee, Bor Heng; You, San Lin; Lin, Ching Yu; Pan, Mei Hung; Chou, Yi Chun; Hsieh, Chang Yao; Chen, Yi Ming A; Cheng, Yu Juen; Chen, Chien Jen.

於: International Journal of Cancer, 卷 129, 編號 4, 15.08.2011, p. 965-973.

研究成果: 雜誌貢獻文章

Chang, YJ, Chen, HC, Lee, BH, You, SL, Lin, CY, Pan, MH, Chou, YC, Hsieh, CY, Chen, YMA, Cheng, YJ & Chen, CJ 2011, 'Unique variants of human papillomavirus genotypes 52 and 58 and risk of cervical neoplasia', International Journal of Cancer, 卷 129, 編號 4, 頁 965-973. https://doi.org/10.1002/ijc.25724
Chang, Ya Ju ; Chen, Hui Chi ; Lee, Bor Heng ; You, San Lin ; Lin, Ching Yu ; Pan, Mei Hung ; Chou, Yi Chun ; Hsieh, Chang Yao ; Chen, Yi Ming A ; Cheng, Yu Juen ; Chen, Chien Jen. / Unique variants of human papillomavirus genotypes 52 and 58 and risk of cervical neoplasia. 於: International Journal of Cancer. 2011 ; 卷 129, 編號 4. 頁 965-973.
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abstract = "Human papillomavirus (HPV) 52 and 58 are oncogenic HPV types prevalent in Asia. Our study aims to explore intratypic variants of HPV 52 and 58 in Taiwan. A total of 11,923 women were enrolled from seven townships in 1991-1992. HPV DNA in their cervical cells was detected and typed by EasyChip{\circledR} HPV blot. Among 424 participants infected with HPV 52 and/or 58, nucleotide variations were determined in cervical cell samples of 406 participants by the polymerase chain reaction sequencing of the long control region, E6 and E7 genes. Nonprototype-like variants including lineages B and C were detected in 278 (99.3{\%}) of 280 HPV 52 samples. The prototype and prototype-like group (lineage A) of HPV58 was found in 132 (98.5{\%}) of 134 HPV 58 samples, with sublineage A1, A2 and A3 variant in 14.2, 27.6 and 56.7{\%}, respectively. Among women infected with single HPV 52 type, the C variant (vs. B variant) was associated with an increased prevalence of cytologically diagnosed high-grade squamous intraepithelial lesion or worse lesions showing an age-adjusted odds ratio (95{\%} confidence interval, CI) of 5.2 (1.0-27.6) and an increased prevalence of histologically confirmed high-grade cervical intraepithelial neoplasia or more severe lesions with an age-adjusted odds ratio (95{\%} CI) of 7.6 (1.3-43.8). It was concluded that frequency distributions of HPV 52 and 58 variants in Taiwan were different from those in European and American populations. The association between C variant of HPV 52 and prevalence of cervical neoplasia needs further validation.",
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AU - Chang, Ya Ju

AU - Chen, Hui Chi

AU - Lee, Bor Heng

AU - You, San Lin

AU - Lin, Ching Yu

AU - Pan, Mei Hung

AU - Chou, Yi Chun

AU - Hsieh, Chang Yao

AU - Chen, Yi Ming A

AU - Cheng, Yu Juen

AU - Chen, Chien Jen

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N2 - Human papillomavirus (HPV) 52 and 58 are oncogenic HPV types prevalent in Asia. Our study aims to explore intratypic variants of HPV 52 and 58 in Taiwan. A total of 11,923 women were enrolled from seven townships in 1991-1992. HPV DNA in their cervical cells was detected and typed by EasyChip® HPV blot. Among 424 participants infected with HPV 52 and/or 58, nucleotide variations were determined in cervical cell samples of 406 participants by the polymerase chain reaction sequencing of the long control region, E6 and E7 genes. Nonprototype-like variants including lineages B and C were detected in 278 (99.3%) of 280 HPV 52 samples. The prototype and prototype-like group (lineage A) of HPV58 was found in 132 (98.5%) of 134 HPV 58 samples, with sublineage A1, A2 and A3 variant in 14.2, 27.6 and 56.7%, respectively. Among women infected with single HPV 52 type, the C variant (vs. B variant) was associated with an increased prevalence of cytologically diagnosed high-grade squamous intraepithelial lesion or worse lesions showing an age-adjusted odds ratio (95% confidence interval, CI) of 5.2 (1.0-27.6) and an increased prevalence of histologically confirmed high-grade cervical intraepithelial neoplasia or more severe lesions with an age-adjusted odds ratio (95% CI) of 7.6 (1.3-43.8). It was concluded that frequency distributions of HPV 52 and 58 variants in Taiwan were different from those in European and American populations. The association between C variant of HPV 52 and prevalence of cervical neoplasia needs further validation.

AB - Human papillomavirus (HPV) 52 and 58 are oncogenic HPV types prevalent in Asia. Our study aims to explore intratypic variants of HPV 52 and 58 in Taiwan. A total of 11,923 women were enrolled from seven townships in 1991-1992. HPV DNA in their cervical cells was detected and typed by EasyChip® HPV blot. Among 424 participants infected with HPV 52 and/or 58, nucleotide variations were determined in cervical cell samples of 406 participants by the polymerase chain reaction sequencing of the long control region, E6 and E7 genes. Nonprototype-like variants including lineages B and C were detected in 278 (99.3%) of 280 HPV 52 samples. The prototype and prototype-like group (lineage A) of HPV58 was found in 132 (98.5%) of 134 HPV 58 samples, with sublineage A1, A2 and A3 variant in 14.2, 27.6 and 56.7%, respectively. Among women infected with single HPV 52 type, the C variant (vs. B variant) was associated with an increased prevalence of cytologically diagnosed high-grade squamous intraepithelial lesion or worse lesions showing an age-adjusted odds ratio (95% confidence interval, CI) of 5.2 (1.0-27.6) and an increased prevalence of histologically confirmed high-grade cervical intraepithelial neoplasia or more severe lesions with an age-adjusted odds ratio (95% CI) of 7.6 (1.3-43.8). It was concluded that frequency distributions of HPV 52 and 58 variants in Taiwan were different from those in European and American populations. The association between C variant of HPV 52 and prevalence of cervical neoplasia needs further validation.

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