First-line drug treatment for tuberculosis (TB) is frequently associated with liver toxicity. The goal of this study was to examine the association between UDP-glucuronosyl- transferase 1A1 (UGT1A1) genetic variations and anti-tuberculosis drug-induced hepatotoxicity (ATDH). A total of 98 patients, including 17 patients with ATDH, were enrolled; compound UGT1A1*27 and UGT1A1*28 were associated with an increased risk for developing ATDH after adjusting for age (OR 13.859; 95%CI 1.085-177.056). These findings require confirmation. However, screening for genetic variations prior to TB treatment may reduce the incidence of ATDH and improve treatment adherence.
|頁（從 - 到）||376-378|
|期刊||International Journal of Tuberculosis and Lung Disease|
|出版狀態||已發佈 - 三月 1 2012|
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Infectious Diseases
Chang, J. C., Liu, E. H., Lee, C. N., Lin, Y. C., Yu, M. C., Bai, K. J., & Chen, H. Y. (2012). UGT1A1 polymorphisms associated with risk of induced liver disorders by anti-tuberculosis medications. International Journal of Tuberculosis and Lung Disease, 16(3), 376-378. https://doi.org/10.5588/ijtld.11.0404