UGT1A1 polymorphisms associated with risk of induced liver disorders by anti-tuberculosis medications

J. C. Chang, E. H. Liu, C. N. Lee, Y. C. Lin, M. C. Yu, K. J. Bai, Hsiang Yin Chen

研究成果: 雜誌貢獻文章

26 引文 斯高帕斯(Scopus)

摘要

First-line drug treatment for tuberculosis (TB) is frequently associated with liver toxicity. The goal of this study was to examine the association between UDP-glucuronosyl- transferase 1A1 (UGT1A1) genetic variations and anti-tuberculosis drug-induced hepatotoxicity (ATDH). A total of 98 patients, including 17 patients with ATDH, were enrolled; compound UGT1A1*27 and UGT1A1*28 were associated with an increased risk for developing ATDH after adjusting for age (OR 13.859; 95%CI 1.085-177.056). These findings require confirmation. However, screening for genetic variations prior to TB treatment may reduce the incidence of ATDH and improve treatment adherence.
原文英語
頁(從 - 到)376-378
頁數3
期刊International Journal of Tuberculosis and Lung Disease
16
發行號3
DOIs
出版狀態已發佈 - 三月 1 2012

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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