Ubiquitination-dependent regulation of signaling receptors in cancer

Wei Chun HuangFu, Serge Y. Fuchs

研究成果: 雜誌貢獻回顧型文獻同行評審

32 引文 斯高帕斯(Scopus)

摘要

Ubiquitination of signaling cell surface receptors is a key mechanism regulating the availability of these receptors to interact with extracellular ligands. Accordingly, this regulation determines the sensitivity of cells to the humoral and locally secreted regulators of cell function, proliferation, and viability. Alterations in receptor ubiquitination and degradation are often encountered in cancers. Malignant cells utilize modified ubiquitination of signaling receptors to augment or attenuate signaling pathways on the basis of whether the outcome of this signaling is conducive or not for tumor growth and survival. These mechanisms as well as their significance for the treatment of human cancers are discussed.
原文英語
頁(從 - 到)725-734
頁數10
期刊Genes and Cancer
1
發行號7
DOIs
出版狀態已發佈 - 2010
對外發佈

ASJC Scopus subject areas

  • 癌症研究
  • 遺傳學

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