Tyrosine sulfation as a protein post-translational modification

Yuh Shyong Yang, Chen Chu Wang, Bo Han Chen, You Hua Hou, Kuo Sheng Hung, Yi Chih Mao

研究成果: 雜誌貢獻文章

32 引文 (Scopus)

摘要

Integration of inorganic sulfate into biological molecules plays an important role in biological systems and is directly involved in the instigation of diseases. Protein tyrosine sulfation (PTS) is a common post-translational modification that was first reported in the literature fifty years ago. However, the significance of PTS under physiological conditions and its link to diseases have just begun to be appreciated in recent years. PTS is catalyzed by tyrosylprotein sulfotransferase (TPST) through transfer of an activated sulfate from 3′-phosphoadenosine-5′-phosphosulfate to tyrosine in a variety of proteins and peptides. Currently, only a small fraction of sulfated proteins is known and the understanding of the biological sulfation mechanisms is still in progress. In this review, we give an introductory and selective brief review of PTS and then summarize the basic biochemical information including the activity and the preparation of TPST, methods for the determination of PTS, and kinetics and reaction mechanism of TPST. This information is fundamental for the further exploration of the function of PTS that induces protein-protein interactions and the subsequent biochemical and physiological reactions.

原文英語
頁(從 - 到)2138-2164
頁數27
期刊Molecules
20
發行號2
DOIs
出版狀態已發佈 - 二月 1 2015

指紋

sulfation
tyrosine
Post Translational Protein Processing
Tyrosine
proteins
Proteins
Sulfates
sulfates
Phosphoadenosine Phosphosulfate
Biological systems
peptides

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

引用此文

Yang, Y. S., Wang, C. C., Chen, B. H., Hou, Y. H., Hung, K. S., & Mao, Y. C. (2015). Tyrosine sulfation as a protein post-translational modification. Molecules, 20(2), 2138-2164. https://doi.org/10.3390/molecules20022138

Tyrosine sulfation as a protein post-translational modification. / Yang, Yuh Shyong; Wang, Chen Chu; Chen, Bo Han; Hou, You Hua; Hung, Kuo Sheng; Mao, Yi Chih.

於: Molecules, 卷 20, 編號 2, 01.02.2015, p. 2138-2164.

研究成果: 雜誌貢獻文章

Yang, YS, Wang, CC, Chen, BH, Hou, YH, Hung, KS & Mao, YC 2015, 'Tyrosine sulfation as a protein post-translational modification', Molecules, 卷 20, 編號 2, 頁 2138-2164. https://doi.org/10.3390/molecules20022138
Yang, Yuh Shyong ; Wang, Chen Chu ; Chen, Bo Han ; Hou, You Hua ; Hung, Kuo Sheng ; Mao, Yi Chih. / Tyrosine sulfation as a protein post-translational modification. 於: Molecules. 2015 ; 卷 20, 編號 2. 頁 2138-2164.
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