Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy

Zai Lin Sheu, Chi Ping Huang, Chao Hsiang Chang, Chung Hsin Chen, Jian Hua Hong, Han Yu Weng, Ta Yao Tai, Shiu Dong Chung, Chi Wen Lo, Thomas Y. Hsueh, Yao Chou Tsai, Yuan Hong Jiang, Bing Juin Chiang, Yung Tai Chen, Jen Tai Lin, Wei Yu Lin, Yeong Chin Jou, Jen Shu Tseng, Chia Chang Wu, Wen Jeng WuHsin Chih Yeh

研究成果: 雜誌貢獻文章同行評審

摘要

Tumor multifocality and location are prognostic factors for upper tract urothelial carcinoma (UTUC). However, confounding effects can appear when these two factors are analyzed together. Therefore, we aimed to investigate the impact of tumor distribution on the outcomes of multifocal UTUC after radical nephroureterectomy. From the 2780 UTUC patients in the Taiwan UTUC Collaboration Group, 685 UTUC cases with multifocal tumors (defined as more than one tumor lesion in unilateral upper urinary tract) were retrospectively included and divided into three groups: multiple renal pelvic tumors, multiple ureteral tumors, and synchronous renal pelvic and ureteral tumors included 164, 152, and 369 patients, respectively. We found the prevalence of carcinoma in situ was the highest in the synchronous group. In multivariate survival analyses, tumor distribution showed no difference in cancer-specific and disease-free survival, but there was a significant difference in bladder recurrence-free survival. The synchronous group had the highest bladder recurrence rate. In summary, tumor distribution did not influence the cancer-specific outcomes of multifocal UTUC, but synchronous lesions led to a higher rate of bladder recurrence than multiple renal pelvic tumors. We believe that the distribution of tumors reflects the degree of malignant involvement within the urinary tract, but has little significance for survival or disease progression.
原文英語
文章編號19059
期刊Scientific Reports
11
發行號1
DOIs
出版狀態已發佈 - 12月 2021

ASJC Scopus subject areas

  • 多學科

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