Tumor-associated macrophages correlate with response to epidermal growth factor receptor-tyrosine kinase inhibitors in advanced non-small cell lung cancer

Fu Tsai Chung, Kang Yun Lee, Chih Wei Wang, Chih Chen Heh, Yao Fei Chan, Huan Wu Chen, Chih Hsi Kuo, Po Hao Feng, Ting Yu Lin, Chun Hua Wang, Chun Liang Chou, Hao Cheng Chen, Shu Min Lin, Han Pin Kuo

研究成果: 雜誌貢獻 › 文章

49 引文 (Scopus)

摘要

Our study investigated whether tumor-associated macrophages (TAMs) in advanced non-small cell lung cancer (NSCLC) are related to treatment response to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) and may be a predictor of survival. Of 206 advanced NSCLC patients treated (first-line) with an EGFR-TKI at the study hospital from 2006 to 2009, 107 with adequate specimens for assessing CD68 immunohistochemistry as a marker of TAMs were assessed. After EGFR-TKI treatment, response was observed in 55 (51%) patients, and the median follow-up period was 13.5 months. Most TAMs were located in the tumor stroma (>95%) and positively costained with the M2 marker CD163. TAM counts were significantly higher in patients with progressive disease than in those without (p <0.0001), a trend that remained in patients with known EGFR mutation status (n = 59) and those with wild-type EGFR (n = 20). High TAM counts, among other factors (e.g., wild-type EGFR), were significantly related to poor progression-free survival (PFS) and overall survival (OS) (all p <0.0001 for TAMs). Multivariate Cox analyses showed that high TAM counts and EGFR mutations were both independent factors associated with PFS [odds ratio (OR), 8.0; 95% confidence interval (CI), 2.87-22.4; p = 0.0001 and OR, 0.03; 95% CI, 0.003-0.31; p = 0.003, respectively] and OS (OR, 2.641; 95% CI, 1.08-6.5; p = 0.03 and OR, 0.14; 95% CI, 0.03-0.56; p = 0.006, respectively). TAMs are related to treatment response irrespective of EGFR mutation and can independently predict survival in advanced NSCLC treated with an EGFR-TKI.
原文英語
期刊International Journal of Cancer
卷131
發行號3
DOIs
出版狀態已發佈 - 八月 1 2012
對外發佈Yes

指紋

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Macrophages
Neoplasms
Odds Ratio
Confidence Intervals
Survival
Mutation
Disease-Free Survival
Tumor Biomarkers
Therapeutics
Multivariate Analysis
Immunohistochemistry

Keywords

  • advanced NSCLC
  • EGFR-TKIs
  • outcome
  • response
  • TAM

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

引用此文

Tumor-associated macrophages correlate with response to epidermal growth factor receptor-tyrosine kinase inhibitors in advanced non-small cell lung cancer. / Chung, Fu Tsai; Lee, Kang Yun; Wang, Chih Wei; Heh, Chih Chen; Chan, Yao Fei; Chen, Huan Wu; Kuo, Chih Hsi; Feng, Po Hao; Lin, Ting Yu; Wang, Chun Hua; Chou, Chun Liang; Chen, Hao Cheng; Lin, Shu Min; Kuo, Han Pin.

於: International Journal of Cancer, 卷 131, 編號 3, 01.08.2012.

研究成果: 雜誌貢獻 › 文章

Chung, FT, Lee, KY, Wang, CW, Heh, CC, Chan, YF, Chen, HW, Kuo, CH, Feng, PH, Lin, TY, Wang, CH, Chou, CL, Chen, HC, Lin, SM & Kuo, HP 2012, 'Tumor-associated macrophages correlate with response to epidermal growth factor receptor-tyrosine kinase inhibitors in advanced non-small cell lung cancer', International Journal of Cancer, 卷 131, 編號 3. https://doi.org/10.1002/ijc.27403
Chung FT, Lee KY, Wang CW, Heh CC, Chan YF, Chen HW 等. Tumor-associated macrophages correlate with response to epidermal growth factor receptor-tyrosine kinase inhibitors in advanced non-small cell lung cancer. International Journal of Cancer. 2012 8月 1;131(3). https://doi.org/10.1002/ijc.27403
Chung, Fu Tsai ; Lee, Kang Yun ; Wang, Chih Wei ; Heh, Chih Chen ; Chan, Yao Fei ; Chen, Huan Wu ; Kuo, Chih Hsi ; Feng, Po Hao ; Lin, Ting Yu ; Wang, Chun Hua ; Chou, Chun Liang ; Chen, Hao Cheng ; Lin, Shu Min ; Kuo, Han Pin. / Tumor-associated macrophages correlate with response to epidermal growth factor receptor-tyrosine kinase inhibitors in advanced non-small cell lung cancer. 於: International Journal of Cancer. 2012 ; 卷 131, 編號 3.
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abstract = "Our study investigated whether tumor-associated macrophages (TAMs) in advanced non-small cell lung cancer (NSCLC) are related to treatment response to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) and may be a predictor of survival. Of 206 advanced NSCLC patients treated (first-line) with an EGFR-TKI at the study hospital from 2006 to 2009, 107 with adequate specimens for assessing CD68 immunohistochemistry as a marker of TAMs were assessed. After EGFR-TKI treatment, response was observed in 55 (51{\%}) patients, and the median follow-up period was 13.5 months. Most TAMs were located in the tumor stroma (>95{\%}) and positively costained with the M2 marker CD163. TAM counts were significantly higher in patients with progressive disease than in those without (p <0.0001), a trend that remained in patients with known EGFR mutation status (n = 59) and those with wild-type EGFR (n = 20). High TAM counts, among other factors (e.g., wild-type EGFR), were significantly related to poor progression-free survival (PFS) and overall survival (OS) (all p <0.0001 for TAMs). Multivariate Cox analyses showed that high TAM counts and EGFR mutations were both independent factors associated with PFS [odds ratio (OR), 8.0; 95{\%} confidence interval (CI), 2.87-22.4; p = 0.0001 and OR, 0.03; 95{\%} CI, 0.003-0.31; p = 0.003, respectively] and OS (OR, 2.641; 95{\%} CI, 1.08-6.5; p = 0.03 and OR, 0.14; 95{\%} CI, 0.03-0.56; p = 0.006, respectively). TAMs are related to treatment response irrespective of EGFR mutation and can independently predict survival in advanced NSCLC treated with an EGFR-TKI.",
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