Triterpene glycosides and phenylpropane derivatives from Staurogyne concinnula possessing anti-angiogenic activity

Thanh Hoa Vo, Yu Chi Lin, Chia Ching Liaw, Wen Pin Pan, Jing Jy Cheng, Ching Kuo Lee, Yao Haur Kuo

研究成果: 雜誌貢獻文章同行評審

摘要

After anti-angiogenic activity screening, the potential n-butanol layer partitioned from the ethanol extract of Staurogyne concinnula was conducted. Further purification by Diaion HP20 column and preparative HPLC chromatography, four undescribed triterpenoid saponin derivatives, along with the known baptisiasaponin I, and four known phenylpropanoid glycosides were isolated and characterized from n-butanol layer. The structures of isolated compounds were elucidated by ESI-MS, 1D, and 2D MNR data. Biological evaluation revealed that baptisiasaponin I possessed significant anti-angiogenic effects (IC50 4.0 ± 0.2 μM). Further mechanism of action of baptisiasaponin I by inhibition of integrin/FAK/paxillin signaling pathway and its downstream effectors as MMP2 and MMP9 are also presented.

原文英語
文章編號112666
期刊Phytochemistry
184
DOIs
出版狀態已發佈 - 四月 2021

ASJC Scopus subject areas

  • 生物化學
  • 分子生物學
  • 植物科學
  • 園藝科學

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