TY - JOUR
T1 - Triterpene acids from the leaves of Planchonella duclitan (Blanco) Bakhuizan
AU - Li, Zong-Huei
AU - Juang, Shin Hun
AU - Hsu, Feng Lin
AU - Wu, Cheng Yi
PY - 2005
Y1 - 2005
N2 - From the methanolic extract of the leaves of Planchonella duclitan, 2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid(1), myrianthic acid (2), 2-hydroxyursolic acid (3), ursolic acid (4), pomolic acid (5), rotundic acid (6), and jacoumaric acid (7) were isolated, and their structures were elucidated on the basis of their spectroscopic analysis. Among them, compound 1 was a new cyclopropyl ursane-type triterpene acid. Additionally, compounds 4 and 7 showed significant cytotoxicity toward human colorectal carcinoma cell line HT29 and human breast carcinoma cell line MCF-7 with IC50 values ranging from 5.8 ± 1.4 to 6.5 ± 1.9 μM.
AB - From the methanolic extract of the leaves of Planchonella duclitan, 2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid(1), myrianthic acid (2), 2-hydroxyursolic acid (3), ursolic acid (4), pomolic acid (5), rotundic acid (6), and jacoumaric acid (7) were isolated, and their structures were elucidated on the basis of their spectroscopic analysis. Among them, compound 1 was a new cyclopropyl ursane-type triterpene acid. Additionally, compounds 4 and 7 showed significant cytotoxicity toward human colorectal carcinoma cell line HT29 and human breast carcinoma cell line MCF-7 with IC50 values ranging from 5.8 ± 1.4 to 6.5 ± 1.9 μM.
KW - 2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid
KW - HT29
KW - Leaves
KW - MCF-7
KW - Planchonella duclitan
KW - Sapotaceae
KW - Triterpene acids
UR - http://www.scopus.com/inward/record.url?scp=33745857648&partnerID=8YFLogxK
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U2 - 10.1002/jccs.200500184
DO - 10.1002/jccs.200500184
M3 - Article
AN - SCOPUS:33745857648
SN - 0009-4536
VL - 52
SP - 1275
EP - 1280
JO - Journal of the Chinese Chemical Society
JF - Journal of the Chinese Chemical Society
IS - 6
ER -