@article{016def379d4b4e448e21a7b4c6439c0e,
title = "Trifunctional Fe3O4/CaP/Alginate Core-Shell-Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy",
abstract = "Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of iron oxide (Fe3O4) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-Fe3O4/CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-Fe3O4/CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-Fe3O4/CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems.",
keywords = "bladder cancer, controlled release, core-shell-corona nanoparticles, magnetic guidance, targeting",
author = "Wang, {Yu Pu} and Liao, {Yu Te} and Liu, {Chia Hung} and Jiashing Yu and Alamri, {Hatem R.} and Alothman, {Zeid A.} and Hossain, {Md Shahriar A.} and Yusuke Yamauchi and Wu, {Kevin C.W.}",
note = "Funding Information: This research was supported by the Ministry of Science and Technology (MOST), Taiwan (103-2113-M-008-001 and 104-2119-M-008-010), National Taiwan University (104R7706), and the National Health Research Institutes of Taiwan (03A1-BNMP14-014). This work was partially supported by the Australian Institute for Innovative Materials (AIIM) Gold/2017 grant. Y.Y and Z.A.A. are grateful to the Deanship of Scientific Research, King Saud University for funding through Vice Deanship of Scientific Research Chairs. The authors would like to thank Dr Macs Bio-Pharma Private Limited and The Pore Fabrication Pty Ltd. (Australia) for helpful contribution to biomedical applications and sample preparation.",
year = "2017",
month = oct,
day = "9",
doi = "10.1021/acsbiomaterials.7b00230",
language = "English",
volume = "3",
pages = "2366--2374",
journal = "ACS Biomaterials Science and Engineering",
issn = "2373-9878",
publisher = "American Chemical Society",
number = "10",
}
