Triflavin, an Arg-Gly-Asp-Containing peptide, inhibits B16-F10 mouse melanoma cell adhesion to matrix proteins via direct binding to tumor cells

J. R. Sheu, T. F. Huang

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)

摘要

Triflavin, an Arg-Gly-Asp (RGD)-containing snake venom peptide, inhibits B16-F10 mouse melanoma cell adhesion to extracellular matrices, e.g., fibronectin, vitronectin, fibrinogen, and collagen type I. In this study, GRGDS inhibits B16-F10 mouse melanoma cell adhesion to immobilized triflavin in a dose-dependent manner. In addition, flow-cytometric analysis and the fluorescence staining method in which FITC-triflavin is utilized as a binding ligand were used. GRGDS inhibits the binding of FITC-triflavin to B16-F10 cells. Additionally, the above results suggest that triflavin directly binds to its receptors expressed on B16-F10 cell surface primarily via its RGD sequence, thereby inhibiting B16-F10 cell adhesion to extracellular matrices.

原文英語
頁(從 - 到)359-364
頁數6
期刊Journal of Biomedical Science
3
發行號5
DOIs
出版狀態已發佈 - 1996

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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