Triflavin, an Arg-Gly-Asp-containing antiplatelet peptide inhibits cell-substratum adhesion and melanoma cell-induced lung colonization

Joen R. Sheu, Chao H. Lin, Jih L. Chung, Che M. Teng, Tur F. Huang

研究成果: 雜誌貢獻文章同行評審

44 引文 斯高帕斯(Scopus)

摘要

Triflavin, an Arg-Gly-Asp (RGD) containing peptide purified from Trimeresurus flavoviridis snake venom, inhibits human platelet aggregation by blocking fibrinogen binding to fibrinogen receptors associated with glycoprotein IIb IIIa complex. In this study, we show that triflavin (1-30 μg/mouse) inhibits B16-F10 melanoma cell-induced lung colonization in C57BL 6 mice in a dose-dependent manner. In vitro, triflavin dose-dependently inhibits adhesion of B16-F10 melanoma cells to extracellular matrices (ECMs; i.e., fibronectin, fibrinogen, vitronectin, and collagen type I). Triflavin is approximately 600-800 times more potent than GRGDS at inhibiting cell adhesion. In addition, triflavin dose-dependently inhibits B16-F10 cell-induced platelet aggregation. These results imply that the inhibitory effect of triflavin on the adhesion of tumor cells to ECMs (e.g., fibronectin, vitronectin and collagen type I) and/or tumor cell-induced platelet aggregation may be partially responsible for its antimetastatic activity in C57BL 6 mice.

原文英語
頁(從 - 到)885-893
頁數9
期刊Japanese Journal of Cancer Research
83
發行號8
出版狀態已發佈 - 8月 1992
對外發佈

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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